INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France; Univ Bordeaux, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, F-33076 Bordeaux, France; Institute of Medical Psychology and Behavioral Immunobiology, Universitätsklinikum Essen, 45 122 Essen, Germany; Department of Clinical Neuroscience, Division for Psychology, Karolinska Institutet, 171 65 Solna, Sweden; Stress Research Institute, Stockholm University, 106 91 Stockholm, Sweden.
Service de Chirurgie Digestive et Pariétale, Clinique Tivoli, F-33000 Bordeaux, France; Clinique Jean Villar, F-33520 Bruges, France.
Brain Behav Immun. 2016 Nov;58:63-68. doi: 10.1016/j.bbi.2016.05.013. Epub 2016 May 17.
Impairment in cognitive flexibility and set shifting abilities has been described in obesity. This alteration is critical as it can interfere with obesity management strategies. Recent evidences suggest that chronic low-grade inflammation may be involved in cognitive deficits associated with obesity, but the potential involvement in reduced flexibility remains unknown. The objective of this study was to assess the contribution of low-grade inflammation, determined by circulating levels of high-sensitivity C-reactive protein (hsCRP), in reduced cognitive flexibility and shifting abilities of obese subjects relatively to a group of non-obese participants. Performance in the intra/extra-dimensional set shift (IED) test, extracted from the CANTAB, was assessed in 66 obese subjects and 20 non-obese participants. Obese subjects with concentrations of hsCRP above 5mg/L exhibited reduced performance on the IED test in comparison to obese subjects with lower levels of hsCRP and non-obese participants. This difference was particularly manifest in the number of errors made during the extra-dimensional shift (EDS errors). In contrast, performance before the extra-dimensional shift was spared. Linear regression analyses revealed that the association between obesity and IED alterations was significant only when the condition hsCRP >5mg/L was entered in the model. These findings are important as they indicate that, rather than obesity itself, low-grade inflammation represents a major contributor of IED performance in obese subjects.
肥胖症患者的认知灵活性和转换能力受损。这种改变至关重要，因为它会干扰肥胖管理策略。最近的证据表明，慢性低度炎症可能与肥胖相关的认知缺陷有关，但在降低灵活性方面的潜在作用尚不清楚。本研究的目的是评估循环高敏 C 反应蛋白 (hsCRP) 水平所代表的低度炎症对肥胖患者认知灵活性和转换能力降低的贡献，相对于非肥胖组参与者。使用 CANTAB 评估了 66 名肥胖患者和 20 名非肥胖参与者的内/外维度转换 (IED) 测试中的表现。与 hsCRP 水平较低的肥胖患者和非肥胖参与者相比，hsCRP 浓度高于 5mg/L 的肥胖患者在 IED 测试中的表现降低，尤其是在进行额外维度转换时的错误数量（EDS 错误）。相比之下，在进行额外维度转换之前，其表现并未受损。线性回归分析表明，只有当模型中包含 hsCRP >5mg/L 这一条件时，肥胖与 IED 改变之间的关联才具有统计学意义。这些发现很重要，因为它们表明，导致 IED 表现改变的主要因素不是肥胖本身，而是低度炎症。
