Kwon Youngjoo
Department of Food Science and Biotechnology, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea.
Cancers (Basel). 2022 Jun 19;14(12):3021. doi: 10.3390/cancers14123021.
BPA, a chemical used in the preparation of polycarbonate plastics, is an endocrine disruptor. Exposure to BPA has been suggested to be a risk factor for breast cancer because of its potential to induce estrogen receptor signaling in breast cancer cells. More recently, it has been recognized that BPA also binds to the G protein-coupled estrogen receptor and other nuclear receptors, in addition to estrogen receptors, and acts on immune cells, adipocytes, and fibroblasts, potentially modulating the TME. The TME significantly impacts the behavior of cancer cells. Therefore, understanding how BPA affects stromal components in breast cancer is imperative to adequately assess the association between exposure to BPA and the risk of breast cancer. This review examines the effects of BPA on stromal components of tumors to highlight their potential role in the carcinogenic effect of BPA. As a result, I propose considerations for the risk assessment of BPA exposure and studies needed to improve understanding of the TME-mediated, breast cancer-promoting effect of BPA.
双酚A（BPA）是一种用于制备聚碳酸酯塑料的化学物质，是一种内分泌干扰物。由于其有可能在乳腺癌细胞中诱导雌激素受体信号传导，接触双酚A被认为是乳腺癌的一个风险因素。最近，人们认识到，除了雌激素受体外，双酚A还与G蛋白偶联雌激素受体和其他核受体结合，并作用于免疫细胞、脂肪细胞和成纤维细胞，可能对肿瘤微环境（TME）产生调节作用。肿瘤微环境对癌细胞的行为有重大影响。因此，了解双酚A如何影响乳腺癌中的基质成分对于充分评估接触双酚A与乳腺癌风险之间的关联至关重要。本综述探讨了双酚A对肿瘤基质成分的影响，以突出它们在双酚A致癌作用中的潜在作用。因此，我提出了关于双酚A暴露风险评估的考虑因素，以及为更好地理解双酚A通过肿瘤微环境介导的促进乳腺癌作用而需要开展的研究。
