Parsania Masoud, Poopak Behzad, Pouriayevali Mohammad Hassan, Haghighi Sama, Amirkhani Aref, Nateghian Alireza
Department of Microbiology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, IR Iran.
Department of Hematology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, IR Iran.
Jundishapur J Microbiol. 2016 Mar 15;9(3):e32974. doi: 10.5812/jjm.32974. eCollection 2016 Mar.
Acute respiratory infection plays an important role in hospitalization of children in developing countries; detection of viral causes in such infections is very important. The respiratory syncytial virus (RSV) is the most common etiological agent of viral lower respiratory tract infection in children, and human metapneumovirus (hMPV) is associated with both upper and lower respiratory tract infections among infants and children.
This study evaluated the frequency and seasonal prevalence of hMPV and RSV in hospitalized children under the age of five, who were admitted to Aliasghar children's hospital of Iran University of Medical Sciences from March 2010 until March 2013.
Nasopharyngeal or throat swabs from 158 hospitalized children with fever and respiratory distress were evaluated for RSV and hMPV RNA by the real-time polymerase chain reaction (PCR) method.
Among the 158 children evaluated in this study, 49 individuals (31.1%) had RSV infection while nine individuals (5.7%) had hMPV infection. Five (55.5%) of the hMPV-infected children were male while four (44.5%) were female and 27 (55.2%) of the RSV-infected patients were females and 22 (44.8%) were males. The RSV infections were detected in mainly < one year old children and hMPV infections were detected mainly in > one year old children. Both RSV and hMPV infections had occurred mainly during winter and spring seasons.
Respiratory syncytial virus was the major cause of acute respiratory infection in children under one-year of age while human metapneumovirus had a low prevalence in this group. The seasonal occurrence of both viruses was the same.
急性呼吸道感染在发展中国家儿童住院治疗中起着重要作用；检测此类感染的病毒病因非常重要。呼吸道合胞病毒（RSV）是儿童病毒性下呼吸道感染最常见的病原体，人偏肺病毒（hMPV）与婴幼儿上、下呼吸道感染均有关联。
本研究评估了2010年3月至2013年3月期间入住伊朗医科大学阿里亚斯加尔儿童医院的5岁以下住院儿童中hMPV和RSV的感染频率及季节性流行情况。
采用实时聚合酶链反应（PCR）法对158例因发热和呼吸窘迫住院的儿童的鼻咽或咽喉拭子进行RSV和hMPV RNA检测。
在本研究评估的158名儿童中，49例（31.1%）感染了RSV，9例（5.7%）感染了hMPV。hMPV感染儿童中5例（55.5%）为男性，4例（44.5%）为女性；RSV感染患者中27例（55.2%）为女性，22例（44.8%）为男性。RSV感染主要发生在1岁以下儿童中，hMPV感染主要发生在1岁以上儿童中。RSV和hMPV感染均主要发生在冬季和春季。
呼吸道合胞病毒是1岁以下儿童急性呼吸道感染的主要病因，而人偏肺病毒在该组儿童中的感染率较低。两种病毒的季节性发病情况相同。
