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调节冷感受器的表面表达。

Modulating the surface expression of cold receptors.

作者信息

Toro Carlos A, Brauchi Sebastian

机构信息

Division of Neuroscience, Oregon National Primate Research Center; Oregon Health & Science University ; Beaverton, OR, USA.

Instituto de Fisiología; Facultad de Medicina; Universidad Austral de Chile ; Valdivia, Chile.

出版信息

Temperature (Austin). 2015 Mar 16;2(2):160-2. doi: 10.1080/23328940.2015.1017087. eCollection 2015 Apr-Jun.

DOI:10.1080/23328940.2015.1017087
PMID:27227017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4843869/
Abstract

Temperature sensing is essential in every organism in order to adapt and survive. However, the mechanisms by which temperature is perceived and detected remain unclear. Recent findings on thermally-activated ion channels have shed light on the puzzle and unravel molecular entities for temperature detection and transduction in mammals.

摘要

温度感知对于每个生物体适应环境并生存下去至关重要。然而,温度被感知和检测的机制仍不清楚。最近关于热激活离子通道的研究结果为这一谜题带来了曙光,并揭示了哺乳动物中用于温度检测和传导的分子实体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c09f/4843869/cbe0816444aa/ktmp-02-02-1017087-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c09f/4843869/cbe0816444aa/ktmp-02-02-1017087-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c09f/4843869/cbe0816444aa/ktmp-02-02-1017087-g001.jpg

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本文引用的文献

1
Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.冷感受器TRPM8细胞表面表达的激动剂依赖性调节
J Neurosci. 2015 Jan 14;35(2):571-82. doi: 10.1523/JNEUROSCI.3820-13.2015.
2
Activity and Ca²⁺ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons.活性和钙离子调节感觉神经元质膜中TRPV1通道的流动性。
Elife. 2015 Jan 8;4:e03819. doi: 10.7554/eLife.03819.
3
A cool channel in cold transduction.冷传导中的冷通道。
Physiology (Bethesda). 2011 Aug;26(4):273-85. doi: 10.1152/physiol.00004.2011.
4
Near-membrane dynamics and capture of TRPM8 channels within transient confinement domains.近膜动力学和瞬时限制域内 TRPM8 通道的捕获。
PLoS One. 2010 Oct 11;5(10):e13290. doi: 10.1371/journal.pone.0013290.
5
Surface mobility of postsynaptic AMPARs tunes synaptic transmission.突触后α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体(AMPARs)的表面迁移率调节突触传递。
Science. 2008 Apr 11;320(5873):201-5. doi: 10.1126/science.1152089.
6
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.磷脂酰肌醇-4,5-二磷酸(PI(4,5)P2)通过瞬时受体电位(TRP)结构域调节瞬时受体电位阳离子通道亚家族M成员8(TRPM8)通道的激活和脱敏。
Nat Neurosci. 2005 May;8(5):626-34. doi: 10.1038/nn1451. Epub 2005 Apr 24.
7
Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.理解冷觉的线索:冷感受器TRPM8的热力学与电生理分析
Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15494-9. doi: 10.1073/pnas.0406773101. Epub 2004 Oct 18.