Bauer T, Vennits B, Holm B, Hahn-Pedersen J, Lysen D, Galatius H, Kristensen E S, Graversen P, Wilhelmsen F, Skjoldborg H
Department of Surgery, General Hospital of Roenne, Denmark.
Ann Surg. 1989 Mar;209(3):307-11. doi: 10.1097/00000658-198903000-00010.
In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.
在一项前瞻性、分组随机、多中心研究中，对头孢西丁用于术前预防的安全性和有效性进行了研究。1735例接受阑尾切除术的患者可进行评估，其中一半患者在手术前接受了2克头孢西丁。患者被分为三组：阑尾正常的患者、阑尾急性发炎的患者和阑尾坏疽的患者。研究表明，对于每组接受预防治疗的患者，伤口感染发生率均显著降低。然而，术前抗生素预防对腹腔内脓肿形成没有影响。因此，建议在阑尾切除术前进行常规术前预防。
