Minabe M, Takeuchi K, Tomomatsu E, Hori T, Umemoto T
Department of Periodontology, Kanagawa Dental College, Japan.
J Clin Periodontol. 1989 May;16(5):291-4. doi: 10.1111/j.1600-051x.1989.tb01657.x.
Tetracycline-containing cross-linked collagen film (TC film), or tetracycline-free placebo film, were locally applied 4 times, at 1-week intervals, to 33 teeth with periodontal pockets larger than 4 mm, in 11 patients with periodontal disease. The clinical and microbiological effects are summarized, as follows. In the group treated with the TC film, (1) the clinical indices were significantly decreased at the 4th and 7th weeks in comparison with those at the beginning of treatment. In particular, this group showed a significant decrease in the incidence of bleeding as compared with the placebo group at the 4th week. (2) Total counts of bacteria in the periodontal pockets showed an obvious tendency to decrease with time. The proportion of black-pigmented bacteroides was significantly decreased at the 4th and 7th weeks when compared with the pretreatment value. The extent of decrease in the proportion of spirochetes at both the 4th and 7th weeks was significant compared with the placebo group and the pretreatment value.
含四环素交联胶原膜（TC膜）或不含四环素的安慰剂膜，以1周的间隔局部应用4次，用于11例牙周病患者的33颗牙周袋大于4mm的牙齿。临床和微生物学效果总结如下。在使用TC膜治疗的组中，（1）与治疗开始时相比，第4周和第7周的临床指标显著降低。特别是，该组在第4周时与安慰剂组相比，出血发生率显著降低。（2）牙周袋中的细菌总数呈现随时间明显下降的趋势。与治疗前值相比，第4周和第7周时黑色色素类杆菌的比例显著降低。与安慰剂组和治疗前值相比，第4周和第7周时螺旋体比例的下降程度均显著。
