Minabe M, Uematsu A, Nishijima K, Tomomatsu E, Tamura T, Hori T, Umemoto T, Hino T
Department of Periodontology, Kanagawa Dental College, Japan.
J Periodontol. 1989 Feb;60(2):113-7. doi: 10.1902/jop.1989.60.2.113.
For the purpose of applying a local drug delivery system to periodontal therapy, atelocollagen preparations with immobilized tetracycline (TC) were prepared by modifying the form of the collagen, the concentration of the immobilized TC, and the time of the cross-link process with glutaraldehyde. The course of the TC release from the collagen preparations into an aqueous solution was determined in relation to time. The preparations were also inserted into periodontal pockets, and the amount of TC remaining in the pocket was determined daily. The results obtained were as follows: 1) The degree of drug release could be controlled to some extent by adjusting the TC concentration and the time of the cross-link process; and 2) an amount of TC exceeding the effective dose in the gingival crevicular fluid was present in the periodontal pocket even 10 days after the insertion of TC fixed in the cross-linked processed collagen film in the periodontal pockets.
为了将局部给药系统应用于牙周治疗，通过改变胶原蛋白的形式、固定化四环素（TC）的浓度以及与戊二醛交联过程的时间，制备了固定化四环素的去端胶原蛋白制剂。测定了胶原蛋白制剂中TC释放到水溶液中的过程与时间的关系。还将制剂插入牙周袋中，每天测定袋中剩余的TC量。得到的结果如下：1）通过调节TC浓度和交联过程的时间，可以在一定程度上控制药物释放程度；2）即使在将固定在交联处理胶原蛋白膜中的TC插入牙周袋10天后，牙周袋中仍存在超过龈沟液有效剂量的TC量。
