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往返之旅：胰岛素、上皮钠通道与皮质集合管。

There and back again: insulin, ENaC, and the cortical collecting duct.

作者信息

Pao Alan C

机构信息

Department of Medicine Stanford University, Stanford, California.

出版信息

Physiol Rep. 2016 May;4(10). doi: 10.14814/phy2.12809.

DOI:10.14814/phy2.12809
PMID:27233302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4886174/
Abstract

Cell culture models suggest mechanisms by which insulin stimulates ENaC in the cortical collecting duct. These mechanisms still need to be tested for physiological significance in animal models of insulin resistance.[Image: see text]

摘要

细胞培养模型揭示了胰岛素刺激皮质集合管中ENaC的机制。这些机制仍需在胰岛素抵抗动物模型中进行生理意义的测试。[图片：见正文]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d8d/4886174/4a03c61691a4/PHY2-4-e12809-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d8d/4886174/4a03c61691a4/PHY2-4-e12809-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d8d/4886174/4a03c61691a4/PHY2-4-e12809-g001.jpg

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2
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Am J Physiol Renal Physiol. 2016 May 1;310(9):F812-20. doi: 10.1152/ajprenal.00265.2015. Epub 2016 Feb 3.
3
Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.
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Sci Rep. 2019 Mar 12;9(1):4296. doi: 10.1038/s41598-019-40639-x.
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