综述：液相色谱与低分辨率和高分辨率质谱联用用于生物基质中新精神活性物质的筛查——我们如今处于什么水平？
Review: LC coupled to low- and high-resolution mass spectrometry for new psychoactive substance screening in biological matrices - Where do we stand today?
作者信息
Meyer Markus R, Maurer Hans H
机构信息
Department of Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
Department of Experimental and Clinical Toxicology, Saarland University, Homburg, Germany.
出版信息
Anal Chim Acta. 2016 Jul 13;927:13-20. doi: 10.1016/j.aca.2016.04.046. Epub 2016 Apr 28.
The field of new psychoactive substances (NPS) is highly dynamic and the situation changes from year to year. Therefore, the current review provides a timely update about the latest developments to help analysts keep the pace with NPS distribution. It covers PubMed-listed studies published between January 2014 and January 2016 dealing with the application of liquid chromatography (LC) coupled low- and high-resolution mass spectrometry (MS) for broad screenings for NPS in clinical (CT) and forensic (FT) toxicology. Latest developments and applications are highlighted and selected papers critically discussed. Comprehensive tables summarizing all discussed articles complete the overview. Finally, an outlook on the future of LC coupled MS in CT and FT is provided and readers will learn why low-resolution mass spectrometry might remain the standard for the next couple of years at least for easy-to-use quantitative screening procedures.
新型精神活性物质（NPS）领域变化极为迅速，情况逐年不同。因此，本综述及时更新了最新进展，以帮助分析人员跟上NPS的流通速度。它涵盖了2014年1月至2016年1月期间发表在PubMed上的研究，这些研究涉及液相色谱（LC）与低分辨率和高分辨率质谱（MS）联用在临床毒理学（CT）和法医毒理学（FT）中对NPS进行广泛筛查的应用。突出介绍了最新进展和应用，并对精选论文进行了批判性讨论。总结所有讨论文章的综合表格完善了综述内容。最后，展望了LC-MS联用技术在临床毒理学和法医毒理学中的未来发展，读者将了解到为什么至少在未来几年内，低分辨率质谱可能仍将是易于使用的定量筛查程序的标准。
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