Saha Avinandan, Botha Stefan Louis, Weaving Paul, Satta Giovanni
Medical Microbiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Medical Microbiology, North Middlesex University Hospital NHS Trust, London, United Kingdom.
Am J Infect Control. 2016 Nov 1;44(11):1247-1251. doi: 10.1016/j.ajic.2016.03.046. Epub 2016 May 26.
Peracetic acid sporicidal wipes have been shown to be an effective disinfectant, but in controlled test environments. Their high cost may restrict use.
This pilot study investigated the efficacy and compared the costs of routine universal use of peracetic acid sporicidal wipes versus sporicidal quaternary ammonium compound and alcohol wipes in the disinfection of a hospital environment.
The routine universal use of peracetic acid wipes (Clinell Sporicidal; GAMA Healthcare Ltd, London, UK) was allocated to a study ward, whereas the control ward continued with the use of quaternary ammonium compound wipes (Tuffie 5; Vernacare, Bolton, UK) and alcohol wipes (PDI Sani-Cloth 70; PDI, Flint, UK). Twenty high-touch areas in the 2 wards were sampled for the presence of indicator organisms. The weekly detection rates of indicator organisms and weekly healthcare associated infection (HCAI) rates in the 2 wards were compared and examined for decreasing trends over the trial period.
The detection rates of indicator organisms and HCAI rates were not significantly different in the 2 wards, and did not decrease significantly over the trial period. However, the peracetic acid wipes seem to be more effective against gram-negative organisms but at a significantly higher cost.
Further prospective studies are needed to assess the cost-effectiveness of peracetic acid wipes.
过氧乙酸杀孢子擦拭巾已被证明是一种有效的消毒剂,但仅限于在受控的测试环境中。其高昂的成本可能会限制其使用。
这项初步研究调查了过氧乙酸杀孢子擦拭巾在医院环境消毒中常规普遍使用的效果,并比较了其与杀孢子季铵化合物和酒精擦拭巾的成本。
将过氧乙酸擦拭巾(Clinell Sporicidal;英国伦敦GAMA Healthcare Ltd公司)的常规普遍使用分配到一个研究病房,而对照病房继续使用季铵化合物擦拭巾(Tuffie 5;英国博尔顿Vernacare公司)和酒精擦拭巾(PDI Sani-Cloth 70;美国弗林特PDI公司)。对两个病房的20个高接触区域进行采样,检测指示微生物的存在情况。比较两个病房指示微生物的每周检出率和每周医疗相关感染(HCAI)率,并检查在试验期间是否有下降趋势。
两个病房指示微生物的检出率和HCAI率没有显著差异,在试验期间也没有显著下降。然而,过氧乙酸擦拭巾似乎对革兰氏阴性菌更有效,但成本要高得多。
需要进一步的前瞻性研究来评估过氧乙酸擦拭巾的成本效益。