Berry Jesse L, Cobrinik David, Kim Jonathan W
The Vision Center at Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, Calif., USA.
Ocul Oncol Pathol. 2016 Apr;2(3):148-52. doi: 10.1159/000442167. Epub 2015 Nov 27.
To report the use of handheld spectral-domain optical coherence tomography (HHSD OCT) to identify and define the intraretinal location of a small retinoblastoma that was not detectable by indirect ophthalmoscopy.
This is a retrospective case report of a tumor identified with HHSD OCT in a single patient.
A 7-week-old male was diagnosed with unilateral group E retinoblastoma in the right eye. An enucleation was completed successfully with histopathologic confirmation of the diagnosis. The normal left eye was monitored for the development of retinoblastoma, and 10 weeks after diagnosis, three new small retinoblastomas were noted in the posterior pole. Identification of the smallest of the three tumors was facilitated by HHSD OCT; it was adjacent to the optic nerve head, and involved the outer nuclear layer, outer plexiform layer, and inner nuclear layer, with the inner retina draping over the tumor.
HHSD OCT can aid the ocular oncologist in the identification of very small retinoblastomas before they are visible to the eye, which allows for earlier and potentially vision-sparing treatment of these lesions. Additionally, the ability to identify these very small tumors and to localize them anatomically within the retinal layers may aid in our understanding of retinoblastoma tumorigenesis.
报告使用手持式光谱域光学相干断层扫描（HHSD OCT）来识别和确定间接检眼镜无法检测到的小视网膜母细胞瘤的视网膜内位置。
这是一份对单例患者使用HHSD OCT识别肿瘤的回顾性病例报告。
一名7周大男性被诊断为右眼单侧E组视网膜母细胞瘤。成功进行了眼球摘除术，组织病理学确诊了该诊断。对正常的左眼进行视网膜母细胞瘤发生情况监测，诊断后10周，在后极部发现了3个新的小视网膜母细胞瘤。HHSD OCT有助于识别这3个肿瘤中最小的一个；它毗邻视神经乳头，累及外核层、外丛状层和内核层，内层视网膜覆盖在肿瘤上。
HHSD OCT可帮助眼科肿瘤学家在肉眼可见之前识别非常小的视网膜母细胞瘤，从而能够对这些病变进行更早且可能保留视力的治疗。此外，识别这些非常小的肿瘤并在视网膜层内对其进行解剖定位的能力可能有助于我们理解视网膜母细胞瘤的肿瘤发生机制。
