Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Adv Exp Med Biol. 2020;1296:349-358. doi: 10.1007/978-3-030-59038-3_21.
Retinoblastoma, an intraocular cancer primarily affecting children, interacts with surrounding intraocular and extraocular structures in the development and progression. Subretinal and vitreous seeds are characteristic features of retinoblastoma, which result from the interaction between the tumor and its environment at the levels of tissue and microenvironment. The retina and vitreous affect the disease course and responses to treatment options. Also, neighboring cells in the retina and physicochemical properties of the tumor microenvironment are related to the biological activities of retinoblastoma tumors. Researches focusing on the tumor environment of retinoblastoma will lead to the development of more effective treatment options, which can revolutionize the prognosis of patients with retinoblastoma.
视网膜母细胞瘤是一种主要影响儿童的眼内癌症，它在发育和进展过程中与周围的眼内和眼外结构相互作用。视网膜下和玻璃体内的播散是视网膜母细胞瘤的特征性表现，这是肿瘤与其所处的组织和微环境相互作用的结果。视网膜和玻璃体影响疾病的进程和对治疗方案的反应。此外，视网膜中的邻近细胞和肿瘤微环境的理化性质与视网膜母细胞瘤肿瘤的生物学活性有关。研究聚焦于视网膜母细胞瘤的肿瘤微环境将导致更有效的治疗方案的发展，这可能会彻底改变视网膜母细胞瘤患者的预后。
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