Aziz Hassan A, Modi Yasha S, Plesec Thomas P, Singh Arun D
Department of Ophthalmology, Cole Eye Institute, Cleveland, Ohio, USA.
Department of Pathology, Robert J. Tomsich Pathology and Laboratory Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Ocul Oncol Pathol. 2016 Apr;2(3):153-5. doi: 10.1159/000441725. Epub 2015 Dec 2.
To report a case of an amelanotic irido-ciliary ring melanoma.
Interventional case report.
A 44-year-old male was followed for asymptomatic amelanotic iris nevus of the right eye that was noted to have a localized ciliary body mass with ring extension along the trabecular meshwork. Fine needle aspiration biopsy was consistent with malignant melanoma. The patient underwent enucleation and remains disease free at 9 years of follow-up. Histopathology revealed malignant melanoma involving the iris and ciliary body with a 360-degree extension along the trabecular meshwork. The tumor was composed of a mixture of spindled and epithelioid cells with scant pigmentation.
Amelanotic irido-ciliary ring melanoma with growth along the trabecular meshwork is a rare form of uveal melanoma that could present as an inconspicuous amelanotic iris mass.
报告一例无色素性虹膜睫状体环黑色素瘤病例。
介入性病例报告。
一名44岁男性因右眼无症状性无色素性虹膜痣接受随访，发现有一个局限性睫状体肿物，并沿小梁网呈环状延伸。细针穿刺活检结果符合恶性黑色素瘤。患者接受了眼球摘除术，随访9年无疾病复发。组织病理学显示恶性黑色素瘤累及虹膜和睫状体，沿小梁网呈360度延伸。肿瘤由梭形细胞和上皮样细胞混合组成，色素沉着稀少。
沿小梁网生长的无色素性虹膜睫状体环黑色素瘤是一种罕见的葡萄膜黑色素瘤形式，可表现为不明显的无色素性虹膜肿物。
