Rabinovich O F, Ivina A A, Guseva A V, Babichenko I I
Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of Russian Federation, Moscow, Russia.
Peoples' Friendship University of Russia, Moscow, Russia.
Stomatologiia (Mosk). 2016;95(2):4-7. doi: 10.17116/stomat20169524-7.
The article is devoted to immunohistochemical study of reticular and erosive forms of oral lichen planus. Morphological examination of the reticular form revealed the increased number of Langerhans cells (CD1a), mast cells (CD25) and T lymphocytes (CD4, CD8, CD16) in the oral epithelium. Activation of these cells leads to the secretion of TNF-α and destruction of basal keratinocytes, which manifests as a focal reduction of intercellular protein expression of E-cadherin. Destruction of basal keratinocytes in a reticular form of oral lichen planus is accompanied by a significant decrease in proliferative activity of the basal cell layer (21.7±10.2%) compared with normal mucosa (33.6±7.0%), p=0.0045. In erosive form along with the above changes IgG and C3d complement's elements are revealed, which confirms the activation of immune complex mechanisms in the erosion area.
本文致力于口腔扁平苔藓网状和糜烂型的免疫组织化学研究。网状型的形态学检查显示，口腔上皮中朗格汉斯细胞（CD1a）、肥大细胞（CD25）和T淋巴细胞（CD4、CD8、CD16）数量增加。这些细胞的激活导致肿瘤坏死因子-α的分泌和基底角质形成细胞的破坏，表现为E-钙黏蛋白细胞间蛋白表达的局灶性减少。与正常黏膜（33.6±7.0%）相比，口腔扁平苔藓网状型中基底角质形成细胞的破坏伴随着基底细胞层增殖活性的显著降低（21.7±10.2%），p = 0.0045。在糜烂型中，除上述变化外，还发现了IgG和C3d补体成分，这证实了糜烂区域免疫复合物机制的激活。
