Brenner D W, Barranco S C, Winslow B H, Shaeffer J
Department of Urology, Eastern Virginia Medical School, Norfolk 23510.
J Pediatr Surg. 1989 Feb;24(2):204-7. doi: 10.1016/s0022-3468(89)80250-7.
Flow cytometric DNA content analyses were performed in a retrospective study of archival tumor specimens of 15 patients with diagnosed neuroblastoma treated at a single institution. Survival statistics were positively influenced by the presence of aneuploidy. Kaplan-Meier analysis indicated a significant survival advantage for patients with aneuploid tumors (P = .036). Survivors were significantly younger at the time of diagnosis than nonsurvivors, but age at diagnosis did not correlate with DNA content. We conclude that DNA content analysis may be of value in determining the prognosis for children with neuroblastoma.
对一家机构治疗的15例确诊神经母细胞瘤患者的存档肿瘤标本进行了流式细胞术DNA含量分析的回顾性研究。非整倍体的存在对生存统计有积极影响。Kaplan-Meier分析表明，非整倍体肿瘤患者有显著的生存优势（P = .036）。幸存者在诊断时的年龄明显小于非幸存者，但诊断时的年龄与DNA含量无关。我们得出结论，DNA含量分析可能对确定神经母细胞瘤患儿的预后有价值。
