Wilson Kayla E, Yang Nuo, Mussell Ashley L, Zhang Jianmin
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Genes (Basel). 2016 May 27;7(6):23. doi: 10.3390/genes7060023.
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks of intracellular and extracellular signaling pathways that modulate YAP and TAZ activities have recently been identified. Among them, KIBRA and PTPN14 are two evolutionarily-conserved and important YAP/TAZ upstream regulators. They can negatively regulate YAP/TAZ functions separately or in concert. In this review, we summarize the current and emerging regulatory roles of KIBRA and PTPN14 in the Hippo pathway and their functions in cancer.
河马信号通路调节细胞增殖和存活，从而对正常细胞命运和肿瘤发生产生深远影响。该通路的关键效应因子是YAP/TAZ，即转录共激活因子，其功能失调会促进癌症的发展。最近已经确定了调节YAP和TAZ活性的细胞内和细胞外信号通路的复杂网络。其中，KIBRA和PTPN14是两个进化保守且重要的YAP/TAZ上游调节因子。它们可以单独或协同负向调节YAP/TAZ的功能。在本综述中，我们总结了KIBRA和PTPN14在河马通路中的当前和新出现的调节作用及其在癌症中的功能。
