Ahmed Atif A, Mohamed Abdalla D, Gener Melissa, Li Weijie, Taboada Eugenio
Department of Pathology, Children's Mercy Hospital, Kansas City, MO, USA.
Institute of Medical Sciences, University of Aberdeen, Scotland, UK.
Mol Cell Oncol. 2017 Feb 25;4(3):e1295127. doi: 10.1080/23723556.2017.1295127. eCollection 2017.
The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis. It is evolutionarily conserved in mammals and is stimulated by cell-cell contact, inhibiting cell proliferation in response to increased cell density. During early embryonic development, the Hippo signaling pathway regulates organ development and size, and its functions result in the coordinated balance between proliferation, apoptosis, and differentiation. Its principal effectors, YAP and TAZ, regulate signaling by the embryonic stem cells and determine cell fate and histogenesis. Dysfunction of this pathway contributes to cancer development in adults and children. Emerging studies have shed light on the upregulation of Hippo pathway members in several pediatric cancers and may offer prognostic information on rhabdomyosarcoma, osteosarcoma, Wilms tumor, neuroblastoma, medulloblastoma, and other brain gliomas. We review the results of such published studies and highlight the potential clinical application of this pathway in pediatric oncologic and pathologic studies. These studies support targeting this pathway as a novel treatment strategy.
河马通路是一条控制细胞增殖和凋亡的重要信号通路。它在哺乳动物中具有进化保守性，受细胞间接触刺激，响应细胞密度增加而抑制细胞增殖。在胚胎早期发育过程中，河马信号通路调节器官发育和大小，其功能导致增殖、凋亡和分化之间的协调平衡。其主要效应分子YAP和TAZ调节胚胎干细胞的信号传导，并决定细胞命运和组织发生。该通路功能失调会导致成人和儿童癌症的发生。新兴研究揭示了河马通路成员在几种儿童癌症中的上调情况，并可能为横纹肌肉瘤、骨肉瘤、肾母细胞瘤、神经母细胞瘤、髓母细胞瘤及其他脑胶质瘤提供预后信息。我们综述了此类已发表研究的结果，并强调了该通路在儿童肿瘤学和病理学研究中的潜在临床应用。这些研究支持将靶向该通路作为一种新型治疗策略。
