Eghbaliferiz Samira, Iranshahi Mehrdad
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran.
Phytother Res. 2016 Sep;30(9):1379-91. doi: 10.1002/ptr.5643. Epub 2016 May 30.
Natural antioxidants, including polyphenols, flavonoids, anthocyanins and carotenoids, play an important role in the treatment and prevention of a large number of diseases. However, studies indicate that natural antioxidants can act as prooxidants, which produce free radicals and cause DNA damage and mutagenesis. The prooxidant activity is typically catalyzed by metals, particularly transition metals such as Fe and Cu, present in biological systems. In this article, we aim to review new in vitro and in vivo evidence of the prooxidant activity of phenolics, flavonoids, anthocyanins and carotenoids. We highlight the role of catalyzing metals, including transition metals, non-transition metals and metalloids, in the prooxidant activity of natural antioxidants. Prooxidant structure-activity relationships of simple phenolics, flavonoids and anthocyanins and the role of cellular antioxidant defense, including endogenous antioxidant compounds and antioxidant enzymes, are also addressed in this review. In addition, we discuss the question, With respect to in vitro evidence of the prooxidant activity of antioxidants, can we translate this activity into biological systems and the human body? Copyright © 2016 John Wiley & Sons, Ltd.
包括多酚、黄酮类化合物、花青素和类胡萝卜素在内的天然抗氧化剂，在大量疾病的治疗和预防中发挥着重要作用。然而，研究表明天然抗氧化剂可充当促氧化剂，产生自由基并导致DNA损伤和诱变。促氧化活性通常由生物系统中存在的金属，特别是铁和铜等过渡金属催化。在本文中，我们旨在综述酚类、黄酮类化合物、花青素和类胡萝卜素促氧化活性的新的体外和体内证据。我们强调了催化金属，包括过渡金属、非过渡金属和类金属，在天然抗氧化剂促氧化活性中的作用。本综述还讨论了简单酚类、黄酮类化合物和花青素的促氧化剂构效关系以及细胞抗氧化防御的作用，包括内源性抗氧化化合物和抗氧化酶。此外，我们探讨了这样一个问题：关于抗氧化剂促氧化活性的体外证据，我们能否将这种活性转化到生物系统和人体中？版权所有© 2016约翰威立父子有限公司。
