• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis.由STAT3激活诱导的miR-182-5p促进胶质瘤肿瘤发生。
Cancer Res. 2016 Jul 15;76(14):4293-304. doi: 10.1158/0008-5472.CAN-15-3073. Epub 2016 May 31.
2
Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion.微小RNA-204-5p表达降低促进胶质瘤进展并推动胶质瘤细胞生长、迁移和侵袭。
PLoS One. 2015 Jul 2;10(7):e0132399. doi: 10.1371/journal.pone.0132399. eCollection 2015.
3
MiR-506 functions as a tumor suppressor in glioma by targeting STAT3.微小RNA-506通过靶向信号转导和转录激活因子3（STAT3）在胶质瘤中发挥肿瘤抑制作用。
Oncol Rep. 2016 Feb;35(2):1057-64. doi: 10.3892/or.2015.4406. Epub 2015 Nov 9.
4
, as a direct upstream regulator of GRIM-19, enhances proliferation and suppresses apoptosis in glioma cells., 作为 GRIM-19 的直接上游调节因子，促进神经胶质瘤细胞的增殖并抑制其凋亡。
Biosci Rep. 2017 Dec 12;37(6). doi: 10.1042/BSR20171038. Print 2017 Dec 22.
5
LINC00511 knockdown suppresses glioma cell malignant progression through miR-15a-5p/AEBP1 axis.LINC00511 敲低通过 miR-15a-5p/AEBP1 轴抑制神经胶质瘤细胞恶性进展。
Brain Res Bull. 2021 Aug;173:82-96. doi: 10.1016/j.brainresbull.2021.05.010. Epub 2021 May 13.
6
MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3.微小RNA-125a-5p通过直接靶向信号转导和转录激活因子3（STAT3）在肺癌细胞中发挥肿瘤抑制作用。
Tumour Biol. 2017 Jun;39(6):1010428317697579. doi: 10.1177/1010428317697579.
7
LncRNA GAS5-AS1 inhibits glioma proliferation, migration, and invasion via miR-106b-5p/TUSC2 axis.长链非编码 RNA GAS5-AS1 通过 miR-106b-5p/TUSC2 轴抑制神经胶质瘤的增殖、迁移和侵袭。
Hum Cell. 2020 Apr;33(2):416-426. doi: 10.1007/s13577-020-00331-z. Epub 2020 Feb 18.
8
MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes.miRNA-106b-5p 通过靶向多个肿瘤抑制基因促进脑肿瘤的发生。
Oncogene. 2014 Oct 2;33(40):4813-22. doi: 10.1038/onc.2013.428. Epub 2013 Oct 28.
9
MicroRNA-34a-5p suppresses tumorigenesis and progression of glioma and potentiates Temozolomide-induced cytotoxicity for glioma cells by targeting HMGA2.miR-34a-5p 通过靶向 HMGA2 抑制胶质瘤的发生发展并增强替莫唑胺诱导的胶质瘤细胞毒性。
Eur J Pharmacol. 2019 Jun 5;852:42-50. doi: 10.1016/j.ejphar.2019.03.005. Epub 2019 Mar 6.
10
MicroRNA-28-5p regulates glioma cell proliferation, invasion and migration by targeting SphK1.微小 RNA-28-5p 通过靶向 SphK1 调节神经胶质瘤细胞的增殖、侵袭和迁移。
Eur Rev Med Pharmacol Sci. 2019 Aug;23(15):6621-6628. doi: 10.26355/eurrev_201908_18551.

引用本文的文献

1
Preliminary exploration of poor prognostic factor IL-33 and its involvement in perioperative immunotherapy in stage II-III lung squamous cell carcinoma: a retrospective cohort study.II-III期肺鳞癌预后不良因素白细胞介素-33及其参与围手术期免疫治疗的初步探索：一项回顾性队列研究
J Thorac Dis. 2024 Sep 30;16(9):6204-6215. doi: 10.21037/jtd-24-1122. Epub 2024 Sep 18.
2
RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc signaling Axis.RNF122 通过 JAK2/STAT3/c-Myc 信号通路促进胶质母细胞瘤生长。
CNS Neurosci Ther. 2024 Sep;30(9):e70017. doi: 10.1111/cns.70017.
3
MRPS16 promotes lung adenocarcinoma growth via the PI3K/AKT/Frataxin signalling axis.MRPS16 通过 PI3K/AKT/Frataxin 信号通路促进肺腺癌生长。
J Cell Mol Med. 2024 Apr;28(7):e18166. doi: 10.1111/jcmm.18166.
4
Mutant p53 Gain-of-Function Induces Migration and Invasion through Overexpression of miR-182-5p in Cancer Cells.突变型 p53 功能获得通过过表达 miR-182-5p 诱导癌细胞迁移和侵袭。
Cells. 2023 Oct 23;12(20):2506. doi: 10.3390/cells12202506.
5
Linc00239 Promotes Colorectal Cancer Development via MicroRNA-182-5p/Metadherin Axis.Linc00239 通过 microRNA-182-5p/Metadherin 轴促进结直肠癌的发展。
Biochem Genet. 2024 Jun;62(3):1727-1741. doi: 10.1007/s10528-023-10510-w. Epub 2023 Sep 11.
6
Downregulation of miR-182-5p by NFIB promotes NAD+ salvage synthesis in colorectal cancer by targeting NAMPT.NFIB 通过靶向 NAMPT 下调 miR-182-5p 促进结直肠癌中 NAD+ 的补救合成。
Commun Biol. 2023 Jul 25;6(1):775. doi: 10.1038/s42003-023-05143-z.
7
Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets.长链非编码RNA和微小RNA在胶质瘤进展中的作用及其作为新型治疗靶点的潜力的见解
Cancers (Basel). 2023 Jun 22;15(13):3298. doi: 10.3390/cancers15133298.
8
FAM72A promotes glioma progression by regulating mitophagy through the Pink1/Parkin signaling pathway.FAM72A通过Pink1/Parkin信号通路调节线粒体自噬，从而促进胶质瘤进展。
J Cancer. 2023 Apr 2;14(6):903-915. doi: 10.7150/jca.82949. eCollection 2023.
9
Roles of STAT3 in the pathogenesis and treatment of glioblastoma.信号转导和转录激活因子3（STAT3）在胶质母细胞瘤发病机制及治疗中的作用。
Front Cell Dev Biol. 2023 Feb 27;11:1098482. doi: 10.3389/fcell.2023.1098482. eCollection 2023.
10
DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid leukemia progression, and determine the sensitivity of BCL2 inhibitor venetoclax.DNA 超甲基化诱导 miR-182 沉默靶向 BCL2 和 HOXA9 以促进白血病干细胞的自我更新，加速急性髓细胞白血病进展，并决定 BCL2 抑制剂 venetoclax 的敏感性。
Theranostics. 2023 Jan 1;13(1):77-94. doi: 10.7150/thno.77404. eCollection 2023.

本文引用的文献

1
miR-429 inhibits glioma invasion through BMK1 suppression.微小RNA-429通过抑制BMK1来抑制神经胶质瘤的侵袭。
J Neurooncol. 2015 Oct;125(1):43-54. doi: 10.1007/s11060-015-1887-x. Epub 2015 Aug 14.
2
MicroRNA biogenesis pathways in cancer.癌症中的微小RNA生物合成途径。
Nat Rev Cancer. 2015 Jun;15(6):321-33. doi: 10.1038/nrc3932.
3
Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells.信号转导与转录激活因子3（Stat3）调控内皮细胞与肿瘤细胞之间的相互作用，抑制Stat3可抑制乳腺癌细胞的脑转移。
Oncotarget. 2015 Apr 30;6(12):10016-29. doi: 10.18632/oncotarget.3540.
4
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.微小RNA-182整合了胶质母细胞瘤中的细胞凋亡、生长和分化程序。
Genes Dev. 2015 Apr 1;29(7):732-45. doi: 10.1101/gad.257394.114.
5
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells.FoxM1驱动一个促进胶质母细胞瘤干细胞样细胞自我更新和致瘤性的前馈STAT3激活信号环。
Cancer Res. 2015 Jun 1;75(11):2337-48. doi: 10.1158/0008-5472.CAN-14-2800. Epub 2015 Apr 1.
6
Signaling-mediated regulation of MicroRNA processing.信号介导的微小RNA加工调控。
Cancer Res. 2015 Mar 1;75(5):783-91. doi: 10.1158/0008-5472.CAN-14-2568. Epub 2015 Feb 6.
7
Tumour suppressor TRIM33 targets nuclear β-catenin degradation.肿瘤抑制因子TRIM33靶向细胞核内β-连环蛋白的降解。
Nat Commun. 2015 Feb 2;6:6156. doi: 10.1038/ncomms7156.
8
MicroRNA-429 functions as a regulator of epithelial-mesenchymal transition by targeting Pcdh8 during murine embryo implantation.在小鼠胚胎植入过程中，微小RNA-429通过靶向Pcdh8发挥上皮-间质转化调节因子的作用。
Hum Reprod. 2015 Mar;30(3):507-18. doi: 10.1093/humrep/dev001. Epub 2015 Jan 21.
9
Promoter methylation of protocadherin8 is an independent prognostic factor for biochemical recurrence of early-stage prostate cancer.原钙黏蛋白 8 启动子甲基化是早期前列腺癌生化复发的独立预后因素。
Med Sci Monit. 2014 Dec 8;20:2584-9. doi: 10.12659/MSM.893083.
10
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.鞘氨醇-1-磷酸裂解酶下调通过STAT3激活的微小RNA促进结肠癌发生。
J Clin Invest. 2014 Dec;124(12):5368-84. doi: 10.1172/JCI74188. Epub 2014 Oct 27.

由STAT3激活诱导的miR-182-5p促进胶质瘤肿瘤发生。

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis.

作者信息

Xue Jianfei, Zhou Aidong, Wu Yamei, Morris Saint-Aaron, Lin Kangyu, Amin Samirkumar, Verhaak Roeland, Fuller Gregory, Xie Keping, Heimberger Amy B, Huang Suyun

机构信息

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Department of Hematology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing, China.

出版信息

Cancer Res. 2016 Jul 15;76(14):4293-304. doi: 10.1158/0008-5472.CAN-15-3073. Epub 2016 May 31.

DOI:10.1158/0008-5472.CAN-15-3073
PMID:27246830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5033679/
Abstract

Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3-induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that abnormal activation or decreased expression of STAT3 promotes or inhibits the expression of miR-182-5p, respectively. Bioinformatics analyses determined that tumor suppressor protocadherin-8 (PCDH8) is a candidate target gene of miR-182-5p. miR-182-5p negatively regulated PCDH8 expression by directly targeting its 3'-untranslated region. PCDH8 knockdown induced the proliferative and invasive capacities of glioma cells. Silencing of PCDH8 or miR-182-5p mimics could reverse the inhibitory effect of WP1066, a STAT3 inhibitor, or STAT3 knockdown in vitro and in vivo on glioma progression. Clinically, expression levels of PCDH8 were inversely correlated with those of p-STAT3 or miR-182-5p in glioblastoma tissues. These findings reveal that the STAT3/miR-182-5p/PCDH8 axis has a critical role in glioma tumorigenesis and that targeting the axis may provide a new therapeutic approach for human glioma. Cancer Res; 76(14); 4293-304. ©2016 AACR.

摘要

恶性胶质瘤是一种常具致命性的癌症类型。STAT3的异常激活会导致胶质瘤的肿瘤发生。STAT3诱导的蛋白质编码基因转录已得到广泛研究；然而，关于STAT3在胶质瘤肿瘤发生过程中调控miRNA基因转录的情况却知之甚少。在本研究中，我们发现STAT3的异常激活或表达降低分别促进或抑制了miR-182-5p的表达。生物信息学分析确定肿瘤抑制因子原钙黏蛋白-8（PCDH8）是miR-182-5p的一个候选靶基因。miR-182-5p通过直接靶向PCDH8的3'非翻译区来负向调控其表达。敲低PCDH8可诱导胶质瘤细胞的增殖和侵袭能力。在体外和体内，敲低PCDH8或转染miR-182-5p模拟物可逆转STAT3抑制剂WP1066或敲低STAT3对胶质瘤进展的抑制作用。在临床上，胶质母细胞瘤组织中PCDH8的表达水平与p-STAT3或miR-182-5p的表达水平呈负相关。这些发现揭示了STAT3/miR-182-5p/PCDH8轴在胶质瘤肿瘤发生中起关键作用，靶向该轴可能为人类胶质瘤提供一种新的治疗方法。《癌症研究》；76(14)；4293 - 304。©2016美国癌症研究协会。