患有妊娠毒血症的奶山羊的葡萄糖不耐受：血液pH值与β-羟基丁酸值之间缺乏相关性。
Glucose intolerance in dairy goats with pregnancy toxemia: Lack of correlation between blood pH and beta hydroxybutyric acid values.
作者信息
Lima Miguel S, Cota João B, Vaz Yolanda M, Ajuda Inês G, Pascoal Rita A, Carolino Nuno, Hjerpe Charles A
机构信息
Faculdade de Medicina Veterinária, CIISA, DC, Universidade de Lisboa, Portugal (Lima, Cota, Vaz, Ajuda); Barão e Barão, Coutada Velha, Benavente, Portugal (Pascoal); INIAV, EUVG, CIISA, Portugal (Carolino); School of Veterinary Medicine, University of California, Davis, California 95616, USA (Hjerpe).
出版信息
Can Vet J. 2016 Jun;57(6):635-40.
This study assessed the response to a glucose tolerance test in dairy goats with pregnancy toxemia (PT), in healthy, pregnant, non-lactating dairy goats in the last month of gestation (HP), and in healthy, lactating, non-pregnant, dairy goats in mid-lactation (HL). A 500 mL volume of a 5% glucose solution was administered by the IV route. Blood glucose concentrations returned to pre-infusion levels by 90 min in all 8 HL goats, and by 180 min in all 8 HP goats. In contrast, concentrations of blood glucose were still significantly above pre-infusion levels at 180 min post-infusion in all 8 PT goats. Thus, marked glucose intolerance was demonstrated in the PT goats, and mild intolerance was noted in the HP goats. In 25 goats diagnosed with PT and having blood beta hydroxybutyric acid (BHBA) values ≥ 2.9 mmol/L, the correlation coefficient for BHBA with blood pH was non-significant.
本研究评估了患有妊娠毒血症（PT）的奶山羊、妊娠最后一个月的健康、妊娠、非泌乳奶山羊（HP）以及泌乳中期的健康、泌乳、非妊娠奶山羊（HL）对葡萄糖耐量试验的反应。通过静脉途径给予500毫升5%的葡萄糖溶液。所有8只HL山羊的血糖浓度在90分钟时恢复到输注前水平，所有8只HP山羊在180分钟时恢复到输注前水平。相比之下，所有8只PT山羊在输注后180分钟时血糖浓度仍显著高于输注前水平。因此，PT山羊表现出明显的葡萄糖不耐受，HP山羊则表现出轻度不耐受。在25只被诊断为PT且血液β-羟基丁酸（BHBA）值≥2.9 mmol/L的山羊中，BHBA与血液pH值的相关系数无统计学意义。
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