Federal Rural University of Pernambuco (UAG/UFRPE), Postgraduate Program in Sanitation and Reproduction of Ruminants, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil.
Cattle Clinic, Campus Garanhuns/UFRPE, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil.
Res Vet Sci. 2020 Jun;130:73-78. doi: 10.1016/j.rvsc.2020.02.016. Epub 2020 Feb 20.
Pregnancy toxemia (PT) is considered one of the most common metabolic diseases with high impact on the production of small ruminants. The objective of this study was investigate possible myocardial damage in goats affected with PT by the determination of serum myocardial biomarkers CK-MB and cTnI. A total of 44 goats affected with PT, and 10 apparently healthy goats (control group or CG) were used in the study. In goats with PT, the serum concentrations of cTnI (0.43 ng/mL) were significantly higher than that in CG goats (0.06 ng/mL). Although CK-MB showed no significant difference, it was approximately three times higher in animals with PT. The serum concentrations of insulin were significantly lower in PT goats (5.03 ppmol/L) compared to CG goats (10.66 pmol/L). The serum concentrations of cortisol in PT goats (155.41 nmol/L) were significantly higher than that in CG goats (36.58 nmol/L). Results of this study indicate that a clinically significant myocardial damage might occur in goats affected with PT leading to significant elevations in values of cTnI and CK-MB. Therefore, these parameters could be used as a potential prognostic indicator in goats affected with this important disease.
妊娠毒血症（PT）被认为是一种最常见的代谢疾病之一，对小反刍动物的生产有很大的影响。本研究的目的是通过测定血清心肌标志物 CK-MB 和 cTnI 来研究患 PT 的山羊是否存在心肌损伤。本研究共使用了 44 只患有 PT 的山羊和 10 只明显健康的山羊（对照组或 CG）。在患有 PT 的山羊中，cTnI（0.43ng/mL）的血清浓度明显高于 CG 山羊（0.06ng/mL）。虽然 CK-MB 没有显著差异，但在 PT 动物中大约是其三倍。PT 山羊的胰岛素血清浓度（5.03 pmol/L）明显低于 CG 山羊（10.66 pmol/L）。PT 山羊的皮质醇血清浓度（155.41 nmol/L）明显高于 CG 山羊（36.58 nmol/L）。本研究结果表明，患 PT 的山羊可能会发生临床意义重大的心肌损伤，导致 cTnI 和 CK-MB 值显著升高。因此，这些参数可以作为该重要疾病患羊的潜在预后指标。
