Veterinary Clinical Sciences, Kansas State University, Manhattan, Kansas, USA.
Veterinary Clinical Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.
J Vet Intern Med. 2021 Mar;35(2):1155-1163. doi: 10.1111/jvim.16069. Epub 2021 Feb 26.
Pregnancy toxemia is a common metabolic disease of periparturient small ruminants. Information on its effects on metabolism and perinatal adaptation of newborn lambs and kids is lacking.
Evaluate differences in morbidity, mortality, and common biochemical and hematologic variables between pregnancy toxemia kids (PT) and control kids (CON).
Sixteen kids born to does being treated at the hospital for pregnancy toxemia (blood beta-hydroxybutyrate concentration [BHB] > 1.2 mmol/L) and 12 kids from healthy dams (dam BHB < 1.2 mmol/L) that kidded at the hospital.
In this cohort study, serial measurements of blood L-lactate, glucose, and BHB concentrations, arterial blood gases, hematocrit, total protein concentrations, nonesterified fatty acids (NEFAs) concentrations, and body weight were compared between groups over the first 72 hours of life. Long-term follow-up was performed after 3 months.
Pregnancy toxemia kids were more likely to require tube feeding at 0 and 12 hours (relative risk 7.7 [1.13, 52.45] and 2.8 [1.39, 5.65]). Pregnancy toxemia kids were more acidemic (7.26 ± 0.069 vs 7.34 ± 0.079, P = .003) and hyperlactatemic (8.17 ± 2.57 vs 5.48 ± 2.71, P = .003) at birth than CON kids. Control kids were 1.1 [1.01, 1.77] times more likely to survive to discharge and 2.2 [1.15, 4.20] times more likely to survive to 3 months than PT kids.
Pregnancy toxemia kids had higher short- and long-term mortality and were more likely to require perinatal intervention. Weight loss in the first few days could be a useful predictor of nonsurvival.
妊娠毒血症是围产期小反刍动物常见的代谢性疾病。关于其对新生羔羊和犊牛代谢和围产期适应的影响的信息尚缺乏。
评估妊娠毒血症羔羊（PT）与对照羔羊（CON）之间发病率、死亡率和常见生化及血液学变量的差异。
16 只出生于在医院接受治疗的患有妊娠毒血症的母羊（血液β-羟丁酸浓度[BHB]＞1.2mmol/L）的羔羊，以及 12 只来自健康母羊（母羊 BHB＜1.2mmol/L）的羔羊。
在这项队列研究中，对两组羔羊在出生后 72 小时内的血 L-乳酸、葡萄糖和 BHB 浓度、动脉血气、红细胞压积、总蛋白浓度、非酯化脂肪酸（NEFA）浓度和体重进行了连续测量。在 3 个月后进行了长期随访。
与 CON 组相比，PT 组在 0 小时和 12 小时更有可能需要管饲（相对风险 7.7[1.13，52.45]和 2.8[1.39，5.65]）。PT 组出生时更酸中毒（7.26±0.069 比 7.34±0.079，P=0.003）和高乳酸血症（8.17±2.57 比 5.48±2.71，P=0.003）。与 PT 组相比，CON 组在出院时的存活率更高（1.1[1.01，1.77]），在 3 个月时的存活率更高（2.2[1.15，4.20]）。
PT 组的短期和长期死亡率更高，更有可能需要围产期干预。出生后几天的体重减轻可能是一个有用的非存活预测指标。
