唾液一氧化氮，一种压力和焦虑的生物标志物？
Salivary Nitric Oxide, a Biomarker for Stress and Anxiety?
作者信息
Gammoh Omar Salem, Al-Smadi Ahmed Mohammad, Ashour Ala Fawzi, Al-Awaida Wajdy
机构信息
Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
Faculty of Sciences, American University of Madaba, Madaba, Jordan.
出版信息
Psychiatry Investig. 2016 May;13(3):311-5. doi: 10.4306/pi.2016.13.3.311. Epub 2016 May 18.
OBJECTIVE
To investigate if salivary nitrate correlates to the daily psychological stress and anxiety in a group of human subjects.
METHODS
The convenient sample recruitment method was employed; data from seventy three subjects were analyzed. The Perceived Stress Scale (PSS) and Hamilton Anxiety Rating Scale (HAM-A) inventories were used to determine stress and anxiety scores respectively. Salivary nitric oxide was measured through nitrate (NOx) levels using the Griess reaction method.
RESULTS
Although stress and anxiety were correlated. No significant correlation exists between salivary nitrate and daily psychological stress and anxiety in the study's participants.
CONCLUSION
While all previous studies focused NOx levels in acute stress models. This is the first study to investigate the correlation between salivary nitrates and daily psychological stress and anxiety. Although stress and anxiety were correlated, there is no correlation between salivary nitrates and daily psychological stress and anxiety. Further studies are required to investigate this correlation using other biological samples such as plasma.
目的
调查一组人类受试者唾液硝酸盐水平是否与日常心理压力和焦虑相关。
方法
采用便利抽样招募方法；分析了73名受试者的数据。分别使用感知压力量表（PSS）和汉密尔顿焦虑评定量表（HAM-A）来确定压力和焦虑得分。采用格里斯反应法通过硝酸盐（NOx）水平测量唾液一氧化氮。
结果
虽然压力和焦虑相关，但在本研究参与者中，唾液硝酸盐与日常心理压力和焦虑之间不存在显著相关性。
结论
以往所有研究都集中在急性应激模型中的NOx水平。这是第一项研究唾液硝酸盐与日常心理压力和焦虑之间相关性的研究。虽然压力和焦虑相关，但唾液硝酸盐与日常心理压力和焦虑之间没有相关性。需要进一步研究使用其他生物样本（如血浆）来调查这种相关性。
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