Wassman E R, Eldridge R, Abuzzahab S, Nee L
Neurology. 1978 Mar;28(3):304-7. doi: 10.1212/wnl.28.3.304.
Clinical and genetic observations of Gilles de la Tourette syndrome were carried out on members of 14 families from the Minneapolis area. An unusual number of the families were of Jewish and other Eastern European ancestry, and in all but one of these families multiple members were affected. These observations parallel our earlier findings based on 21 families from the New York City area. Together with recent evidence indicating relative instability of a specific enzyme in some patients, these observations suggest that there is a genetically determined form of Gilles de la Tourette syndrome.
对明尼阿波利斯地区14个家族的成员进行了抽动秽语综合征的临床和遗传学观察。这些家族中犹太人和其他东欧血统的人数异常之多，除其中一个家族外，其他家族均有多名成员患病。这些观察结果与我们早期基于纽约市地区21个家族得出的发现相似。再加上最近有证据表明一些患者体内一种特定酶相对不稳定，这些观察结果表明，抽动秽语综合征存在一种由基因决定的类型。
