Turner T, Edery M, Mills K T, Bern H A
Department of Zoology, University of California, Berkeley 94720.
J Steroid Biochem. 1989 Apr;32(4):559-64. doi: 10.1016/0022-4731(89)90390-7.
Perinatal exposure to the synthetic estrogen, diethylstilbestrol (DES), affects the structure of both male and female reproductive systems. Changes may also occur in the levels of steroid hormone receptors. Cytosolic and nuclear androgen and estrogen receptor levels (expressed per mg DNA) from the sex accessory glands of male BALB/c mice exposed neonatally to DES were analyzed by exchange assays. Neonatal DES exposure caused significant decreases in: (1) cytosolic androgen and cytosolic and nuclear estrogen receptor levels in the anterior prostate and (2) cytosolic estrogen receptor levels in the ventral prostate. A significant increase was seen in the cytosolic estrogen receptor levels in the seminal vesicle. Significant decreases in cytosolic protein levels occurred in all DES-exposed glands.
围产期暴露于合成雌激素己烯雌酚（DES）会影响雄性和雌性生殖系统的结构。类固醇激素受体水平也可能发生变化。通过交换分析法分析了新生期暴露于DES的雄性BALB/c小鼠性腺中胞质和核雄激素及雌激素受体水平（以每毫克DNA表示）。新生期暴露于DES导致以下各项显著降低：（1）前列腺中胞质雄激素以及胞质和核雌激素受体水平；（2）腹侧前列腺中胞质雌激素受体水平。精囊中的胞质雌激素受体水平显著升高。所有暴露于DES的腺体中胞质蛋白水平均显著降低。
