外环氧菌素B和法瑞腙C，两种源自南极真菌青霉属菌株HDN14 - 431的新生物碱。

Exopisiod B and farylhydrazone C, two new alkaloids from the Antarctic-derived fungus Penicillium sp. HDN14-431.

作者信息

Zhang Ting, Zhu Mei-Lin, Sun Guang-Yu, Li Na, Gu Qian-Qun, Li De-Hai, Che Qian, Zhu Tian-Jiao

机构信息

a Key Laboratory of Marine Drugs, Chinese Ministry of Education , School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003 , China.

出版信息

J Asian Nat Prod Res. 2016 Oct;18(10):959-65. doi: 10.1080/10286020.2016.1174699. Epub 2016 Jun 1.

DOI:10.1080/10286020.2016.1174699

PMID:27249624

Abstract

Two new compounds, exopisiod B (1) and farylhydrazone C (2), together with two known compounds (3-4), were isolated from the Antarctic-derived fungus Penicillium sp. HDN14-431. Their structures including absolute configurations were elucidated by spectroscopic methods and TDDFT ECD calculations. The cytotoxicity and antimicrobial activities of all compounds were tested.

摘要

从源自南极的青霉菌 Penicillium sp. HDN14-431 中分离出两种新化合物，即外孢菌素 B（1）和芳基腙 C（2），以及两种已知化合物（3 - 4）。通过光谱方法和 TDDFT ECD 计算确定了它们的结构，包括绝对构型。测试了所有化合物的细胞毒性和抗菌活性。