Lira Amanda Bastos, de Sousa Rodrigues Célio Fernando
Medical Sleep and ENT of Santa Casa Hospital, Professora Hígia Vasconcelos street, 193, Ponta verde, Maceió, Alagoas, 57035-140, Brazil.
University of Alagoas/Brazil, Maceió, Alagoas, Brazil.
Sleep Breath. 2016 Dec;20(4):1155-1160. doi: 10.1007/s11325-016-1367-3. Epub 2016 Jun 2.
The hypoxia and reoxygenation cycles in obstructive sleep apnea syndrome (OSAS) cause a change in the oxidative balance, leading to the formation of reactive oxygen species capable of reacting with other organic molecules impairing their functions. This study aimed to determine the best markers of oxidative stress in OSAS and what better antioxidant agent to be used to treat the disease.
Searches were conducted in three different databases (PubMed, LILACS, SCIELO), using as descriptors the terms obstructive sleep apnea, oxidative stress, and antioxidant therapy. A total of 120 articles were found but only those considered of interest to the research were selected. Thus, 10 articles were included for further analysis regarding the biomarkers of oxidative stress in OSAS, and 6 articles to evaluate the antioxidant most often used for demonstration of efficacy.
The thioredoxin, malondialdehyde, superoxide dysmutase, and reduced iron were the most commonly used biomarkers and showed a more consistent relationship between increased oxidative stress and OSAS. As antioxidant therapy, vitamin C and N-acetylcysteine (NAC) presented interesting results as a reduction of oxidative stress, which may become an alternative to the complementary treatment of OSAS.
This review's findings agree mostly to measure that the markers of oxidative stress in OSAS may be a contributing aspect to assessment and monitoring of patient, and the antioxidant therapy appears to be beneficial in the treatment of OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）中的缺氧和复氧循环会导致氧化平衡发生变化，从而产生能够与其他有机分子发生反应并损害其功能的活性氧。本研究旨在确定OSAS中氧化应激的最佳标志物以及用于治疗该疾病的更佳抗氧化剂。
在三个不同的数据库（PubMed、LILACS、SCIELO）中进行检索，使用阻塞性睡眠呼吸暂停、氧化应激和抗氧化治疗等术语作为描述词。共找到120篇文章，但仅选择那些被认为对该研究有意义的文章。因此，纳入了10篇文章用于进一步分析OSAS中氧化应激的生物标志物，以及6篇文章用于评估最常用于证明疗效的抗氧化剂。
硫氧还蛋白、丙二醛、超氧化物歧化酶和还原铁是最常用的生物标志物，并且在氧化应激增加与OSAS之间呈现出更一致的关系。作为抗氧化治疗，维生素C和N-乙酰半胱氨酸（NAC）在减轻氧化应激方面呈现出有意义的结果，这可能成为OSAS辅助治疗的一种选择。
本综述的研究结果大多一致表明，OSAS中氧化应激的标志物可能是评估和监测患者的一个重要方面，并且抗氧化治疗似乎对OSAS的治疗有益。
