Hoffman M Camille, D'Anna-Hernandez Kimberly, Benitez Patrick, Ross Randal G, Laudenslager Mark L
Departments of Obstetrics and Gynecology and Psychiatry, University of Colorado School of Medicine, Denver Health and Hospital Authority, Denver, Colorado.
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Dev Psychobiol. 2017 Jan;59(1):123-127. doi: 10.1002/dev.21433. Epub 2016 Jun 3.
Fetal cortisol may be reflected in hair collected shortly after birth. The objective of this study was to determine the range of human fetal hair cortisol concentrations (HCC) in live-born neonates using an approach for processing small quantities of hair.
Hair was cut on the day of birth from neonates and their mothers, born between 26 and 42 weeks gestational age (GA). HCC was determined by enzyme immunoassay. Maternal sociodemographics and birth data were collected. T-tests, ANOVA, Pearson correlation, and Wilcoxon Signed Rank test were used as appropriate.
Ninety maternal and neonatal hair samples were cut from 79 term (T) and 11 preterm (PT) delivered pregnancies. All samples weighed ≥2.5 mg. Fetal HCC correlated with GA (r = .25, p = .02) and birth weight (r = .25, p = .03) and was lower in PT (4.3 ± .3 LN pg/mg) than T (5.3 ± .1, LN pg/mg, p < .001) neonates. No significant relationships were seen between fetal HCC and maternal characteristics or maternal HCC. Fetal HCC was significantly higher than maternal HCC.
Fetal cortisol exposure was determined using this approach for processing small amounts of hair. Preterm neonates have significantly lower HCC than term neonates and fetal HCC is associated with GA at delivery and birth weight. Fetal HCC is significantly higher than maternal HCC cut on the same day. These data provide novel information on the intrauterine fetal cortisol environment.
出生后不久采集的毛发中可能会反映出胎儿的皮质醇水平。本研究的目的是采用一种处理少量毛发的方法，确定活产新生儿的人胎儿毛发皮质醇浓度（HCC）范围。
从孕龄（GA）在26至42周之间的新生儿及其母亲出生当天采集毛发。通过酶免疫测定法测定HCC。收集产妇的社会人口统计学和出生数据。根据情况使用t检验、方差分析、Pearson相关性分析和Wilcoxon符号秩检验。
从79例足月（T）和11例早产（PT）分娩的孕妇中采集了90份母婴毛发样本。所有样本重量≥2.5毫克。胎儿HCC与GA（r = 0.25，p = 0.02）和出生体重（r = 0.25，p = 0.03）相关，PT新生儿的HCC（4.3±0.3 LN pg/mg）低于足月新生儿（5.3±0.1，LN pg/mg，p < 0.001）。未发现胎儿HCC与母亲特征或母亲HCC之间存在显著关系。胎儿HCC显著高于母亲HCC。
采用这种处理少量毛发的方法确定了胎儿皮质醇暴露情况。早产新生儿的HCC显著低于足月新生儿，胎儿HCC与分娩时的GA和出生体重相关。胎儿HCC显著高于同一天采集的母亲HCC。这些数据提供了关于子宫内胎儿皮质醇环境的新信息。
