Takeshima H, Nishimura S, Matsumoto T, Ishida H, Kangawa K, Minamino N, Matsuo H, Ueda M, Hanaoka M, Hirose T
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Nature. 1989 Jun 8;339(6224):439-45. doi: 10.1038/339439a0.
The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.
通过对兔骨骼肌肌浆网中兰尼碱受体（ryanodine receptor）的互补DNA进行克隆和测序，已推断出其由5037个氨基酸组成的序列。预测结构表明，钙释放通道活性存在于受体分子的C末端区域，而其余部分则构成跨越肌浆网与横小管之间连接间隙的“足”结构。
