Ageing Research Center and Translational Medicine-CeSI-MeT, 66100 Chieti, Italy.
Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.
Int J Mol Sci. 2018 Feb 3;19(2):459. doi: 10.3390/ijms19020459.
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional structure of the genome is exploited by cancer cells to promote tumorigenesis. This reprogramming occurs because of hereditable chromatin chemical modifications and the consequent formation of RNA-protein-DNA complexes that represent the principal actors of the epigenetic phenomena. In this regard, the deregulation of a transcribed non-coding RNA may be both cause and consequence of a cancer-related epigenetic alteration. This review summarizes recent findings that implicate microRNAs in the aberrant epigenetic regulation of cancer cells.
通过重塑基因组的三维结构来重新编程转录电路的能力被癌细胞利用来促进肿瘤发生。这种重编程是由于可遗传的染色质化学修饰以及随后形成的 RNA-蛋白质-DNA 复合物引起的，这些复合物代表了表观遗传现象的主要因素。在这方面，转录非编码 RNA 的失调可能是与癌症相关的表观遗传改变的原因和结果。这篇综述总结了最近的发现，表明 microRNAs 参与了癌细胞异常的表观遗传调控。
