归国旅行者中寨卡病毒的临床谱

The Clinical Spectrum of Zika Virus in Returning Travelers.

作者信息

Meltzer Eyal, Leshem Eyal, Lustig Yaniv, Gottesman Giora, Schwartz Eli

机构信息

Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Israel.

The Central Virology Laboratory, Ministry of Health at the Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Am J Med. 2016 Oct;129(10):1126-30. doi: 10.1016/j.amjmed.2016.04.034. Epub 2016 May 31.

DOI:10.1016/j.amjmed.2016.04.034

PMID:27260832

Abstract

INTRODUCTION

The clinical spectrum of Zika virus had, to date, been described in small series from endemic/epidemic countries and is not well established.

METHODS

We describe the clinical manifestations of laboratory-proven Zika virus infection in Israeli travelers during December 2015-February 2016, and review all published cases of travel-related Zika virus.

RESULTS

During the study period, 8 returning Israeli travelers were diagnosed with Zika virus infection. In addition, 41 published cases were included, mostly from Latin America to Europe and North America. Overall, 65.3% were diagnosed by polymerase chain reaction. Rash was the most frequent symptom, present in 95.7% of cases, followed by fever and arthralgia. Conjunctivitis was present in 53.1%; however, only 40.3% presented with a triad of conjunctivitis, fever, and rash. Less frequent symptoms included dysgeusia and nightmares, which, together with arthralgia, persisted for several weeks in some travelers.

CONCLUSIONS

Zika virus clinical picture in travelers is diverse. Prolonged symptoms may occur.

摘要

引言

迄今为止，寨卡病毒的临床症状仅在来自地方性/流行国家的少数病例系列中有过描述，尚未完全明确。

方法

我们描述了2015年12月至2016年2月期间，经实验室确诊的以色列旅行者感染寨卡病毒的临床表现，并回顾了所有已发表的与旅行相关的寨卡病毒病例。

结果

在研究期间，8名回国的以色列旅行者被诊断为感染寨卡病毒。此外，还纳入了41例已发表的病例，大多来自拉丁美洲至欧洲和北美洲。总体而言，65.3%的病例通过聚合酶链反应确诊。皮疹是最常见的症状，95.7%的病例出现该症状，其次是发热和关节痛。53.1%的病例出现结膜炎；然而，只有40.3%的病例同时出现结膜炎、发热和皮疹三联征。较少见的症状包括味觉障碍和噩梦，部分旅行者的关节痛以及这些症状会持续数周。