Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Virus Res. 2018 Aug 2;254:15-20. doi: 10.1016/j.virusres.2017.07.025. Epub 2017 Aug 12.
The 2015 Brazilian Zika virus outbreak sparked a rapid response to control the spread of the virus. What was first understood to be a mild self-resolving infection is now linked to significant neurological defects in both neonates and adults. The WHO declared the 2016 Zika epidemic a public health emergency and issued an unprecedented recommendation to women in affected regions to delay pregnancy until the risks surrounding Zika virus could be understood, or the epidemic contained. Since that time, considerable effort has been dedicated to understanding Zika transmission and pathogenesis to aid the development of drugs and vaccines. Several models have emerged to study numerous facets of Zika biology; this review details the various model systems.
2015 年巴西寨卡病毒爆发引发了一场快速反应，以控制病毒的传播。最初被认为是一种轻微的自限性感染，现在与新生儿和成年人的严重神经缺陷有关。世界卫生组织宣布 2016 年寨卡疫情为公共卫生紧急事件，并发布了一项前所未有的建议，要求受影响地区的妇女推迟怀孕，直到能够了解寨卡病毒的风险，或疫情得到控制。从那时起，人们投入了大量精力来了解寨卡病毒的传播和发病机制，以帮助开发药物和疫苗。已经出现了几种模型来研究寨卡生物学的众多方面；本综述详细介绍了各种模型系统。
