Sharifi-Rad M, Tayeboon G S, Sharifi-Rad J, Iriti M, Varoni E M, Razazi S
Zabol University of Medical Sciences Zabol Iran.
Payamenoor University Department of Biology Tehran Iran.
Cell Mol Biol (Noisy-le-grand). 2016 May 30;62(6):80-5.
Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P<0.05) inhibited α-glucosidase (IC50 532.97 µg/mL), whereas conjugated phenolic extract significantly (P<0.05) inhibited α-amylase (IC50 489.73 µg/mL) and ACE (290.06 µg/mL). The enzyme inhibitory activities of the extracts were not associated with their phenolic content. Anyway, the inhibition of α-amylase, α-glucosidase and ACE, along with the antioxidant capacity of the phenolic-rich extracts, could represent a putative mechanism through which V. persica exerts its antidiabetes and antihypertension effects.
婆婆纳属（车前科）广泛分布于不同的生境中。在本研究中，评估了波斯婆婆纳游离可溶性酚类提取物和结合酚类提取物对与2型糖尿病相关的关键酶（α-葡萄糖苷酶和α-淀粉酶）以及高血压相关的关键酶（血管紧张素I转换酶，ACE）的抑制活性，以及它们的抗氧化能力。我们的结果表明，两种提取物均以剂量依赖性方式抑制α-淀粉酶、α-葡萄糖苷酶和ACE。特别是，游离酚类提取物显著（P<0.05）抑制α-葡萄糖苷酶（IC50为532.97 µg/mL），而结合酚类提取物显著（P<0.05）抑制α-淀粉酶（IC50为489.73 µg/mL）和ACE（290.06 µg/mL）。提取物的酶抑制活性与其酚类含量无关。无论如何，对α-淀粉酶、α-葡萄糖苷酶和ACE的抑制作用，以及富含酚类提取物的抗氧化能力，可能代表了波斯婆婆纳发挥其抗糖尿病和抗高血压作用的一种潜在机制。
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