Shimao Tadao
Kekkaku. 2016 Feb;91(2):69-74.
Modern National Tuberculosis Program (NTP) of Japan started in 1951 when Tuberculosis (TB) Control Law was legislated, and 3 major components were health examination by tuberculin skin test (TST) and miniature X-ray, BCG vaccination and extensive use of modern TB treatment. As to the treatment program, Japan introduced Public-Private Mix (PPM) from the very beginning, and major reasons why PPM was adopted are (1) TB was then highly prevalent (Table 1), (2) TB sanatoria where many specialists are working are located in remote inconvenient places due to stigma against TB, (3) health centers (HCs) in Japan are working exclusively on prophylactic activities, and minor exceptions are treatment of sexually transmitted diseases and artificial pneumothorax for TB cases, however, as it covers on the average 100,000 population, access is not so easy in rural area, (4) Out-patients clinics mainly operated by general practitioners (GPs) are located throughout Japan, and the access is easy. Methods of TB treatment was developing rapidly in early 1950s, however, in 1952, as shown in Table 2, artificial pneumothorax and peritoneum were still used in many cases, and to fix the dosage of refill air, fluoroscopy was needed. Hence, GPs treating TB under TB Control Law had to be equipped with X-ray apparatus. To maintain the quality of TB treatment, "Criteria for TB treatment" was provided and revised taking into consideration the progress in TB treatment. If applied methods of treatment fit with the above criteria, public support is made for the cost of TB treatment. To discuss the applied treatment, TB Advisory Committee was set in each HC, composing of 5 members, director of HC, 2 TB specialists and 2 doctors recommended by the local medical association. In 1953, the first TB prevalence survey using stratified random sampling method was carried out, and the prevalence of TB requiring treatment was estimated at 3.4%, and only 21% of found cases knew their own disease, and more than half of all TB were found above 30 years of age. Based on these results, mass screening was expanded to cover whole population in 1955, and since 1957, cost of mass screening and BCG vaccination was covered 100% by public fund. Unified TB registration system covering whole Japan was introduced in 1961, and in the same year, national government subsidy for the hospitalization of infectious TB cases was raised from 50% to 80%. Hence, Japan succeeded to organize PPM system in TB care, and with 10% annual decline of TB, in 1975, Japan moved into the TB middle prevalence country.
日本现代国家结核病防治规划(NTP)始于1951年《结核病防治法》立法之时,其三大主要组成部分为结核菌素皮肤试验(TST)和小型X线检查进行的健康检查、卡介苗接种以及广泛使用现代结核病治疗方法。关于治疗规划,日本从一开始就引入了公私合作模式(PPM),采用PPM的主要原因包括:(1)当时结核病高度流行(表1);(2)由于对结核病的污名化,许多专科医生工作的结核病疗养院位于偏远不便之地;(3)日本的保健中心(HCs)专门从事预防活动,少数例外情况是性传播疾病的治疗以及结核病患者的人工气胸治疗,然而,由于其平均覆盖10万人口,在农村地区就医并不容易;(4)主要由全科医生(GPs)运营的门诊遍布日本各地,就医方便。20世纪50年代初结核病治疗方法迅速发展,然而,如表2所示,1952年许多病例仍在使用人工气胸和人工气腹,为确定补充空气的剂量,需要进行荧光透视检查。因此,根据《结核病防治法》治疗结核病的全科医生必须配备X线设备。为保持结核病治疗质量,制定并根据结核病治疗进展修订了“结核病治疗标准”。如果应用的治疗方法符合上述标准,公共资金将为结核病治疗费用提供支持。为讨论应用的治疗方法,每个保健中心都设立了结核病咨询委员会,由5名成员组成,即保健中心主任、2名结核病专家以及当地医学协会推荐的2名医生。1953年,首次采用分层随机抽样方法进行结核病患病率调查,估计需要治疗的结核病患病率为3.4%,仅21%的确诊病例知道自己患病,所有结核病患者中超过一半是30岁以上人群。基于这些结果,1955年大规模筛查扩大到覆盖全体人口,自1957年起,大规模筛查和卡介苗接种费用由公共资金100%承担。1961年引入了覆盖全日本的统一结核病登记系统,同年,国家政府对传染性结核病患者住院治疗的补贴从50%提高到80%。因此,日本成功组织了结核病防治的公私合作模式体系,随着结核病患病率每年下降10%,1975年日本进入结核病中等流行国家。