Malekasgar Ali Mohammad
Turk J Haematol. 2004 Dec 5;21(4):181-7.
The relation of ABO blood groups to disease is well established. In 1943, Levine had identified ABO incompatibility as a cause of early abortions and stillbirths. From this time onwards numerous workers produced data suggesting, mainly on the grounds of a deficiency of A children, and an excess of abortions, in the families of O women married to A men, that the A fetuses produced by such mating were especially liable to be aborted. Seventy-nine couples from Pune city (India), suffering from repeated abortion have been investigated for the ABO blood groups system to find out the frequency of ABO blood group phenotypes and ABO incompatibility as a cause of abortion. In husband group maximum number of individuals had blood group A. In wife group, blood group B showed the highest number of individuals. In mixed group 154 patients have been tested and out of these, again blood group A, shows the highest number of individuals. Blood group "A" and "AB" was significantly higher in individual and mixed groups as compared with normal groups in this study. ABO blood group of husband/wife mating was also determined, the analysis of husband/wife joint "ABO" blood group distribution in these couples, shows an excess of joint "A/B" blood groups in couples as compared with expected proportions assuming random mating. This study came to a conclusion that there is a clear increase in number of individuals for blood group A and AB in-patients with repeated abortion, and this factor may need to pay more attention in future investigations. It is possible that incompatibility of the antigens present in red blood cell membrane of husband/wife may play some role in abortion.
ABO血型与疾病的关系已得到充分证实。1943年，莱文确定ABO血型不合是早期流产和死产的一个原因。从那时起，许多研究人员提供的数据表明，主要基于与A血型男性结婚的O血型女性家庭中A型子女数量不足以及流产过多的情况，这种配偶关系所孕育的A型胎儿尤其容易流产。对来自印度浦那市的79对反复流产的夫妇进行了ABO血型系统调查，以找出ABO血型表型的频率以及ABO血型不合作为流产原因的情况。在丈夫组中，A型血的个体数量最多。在妻子组中，B型血的个体数量最多。在混合组中，对154名患者进行了检测，其中同样是A型血的个体数量最多。在本研究中，个体组和混合组中“A”型和“AB”型血的比例明显高于正常组。还确定了夫妻的ABO血型，对这些夫妇的夫妻联合“ABO”血型分布进行分析，结果显示与随机交配的预期比例相比，夫妻联合“A/B”血型的比例过高。本研究得出结论，反复流产的住院患者中，A型和AB型血的个体数量明显增加，这一因素在未来的研究中可能需要更多关注。夫妻红细胞膜上存在的抗原不相容可能在流产中起一定作用。
