Rout Bhimsen
Organic Chemistry Division, Institute of Chemical and Engineering Sciences, A*STAR, 138665-Singapore.
Sci Rep. 2016 Jun 7;6:27115. doi: 10.1038/srep27115.
The efficacy of a miniaturized unimolecular analytic system is illustrated. The easily accessible therapeutic chromophore "temoporfin", which responds differentially to bound metals at multiple wavelengths of Q-band absorption using chemometric analysis, expeditiously detects and discriminates a wide range of metals regarded as priority pollutants in water and hence may also be used for diagnosis of medically relevant metals in human urine. The molecule was further investigated as an electronic logic device, e.g. keypad lock device, to authorize multiple highly secure chemical passwords for information protection.
本文展示了一种小型化单分子分析系统的功效。易于获取的治疗性发色团“替莫泊芬”，利用化学计量分析在Q波段吸收的多个波长下对结合金属有不同响应，能快速检测和区分多种被视为水中优先污染物的金属，因此也可用于诊断人体尿液中与医学相关的金属。该分子还被进一步研究作为一种电子逻辑器件，如键盘锁定装置，以授权多个高度安全的化学密码来保护信息。
