Piccirilli Joseph A, Staley Jonathan P
Department of Biochemistry and Molecular Biology, and the Department of Chemistry, University of Chicago, Chicago, Illinois, USA.
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, USA.
Nat Struct Mol Biol. 2016 Jun 7;23(6):507-9. doi: 10.1038/nsmb.3242.
The first high resolution structural views of group II intron maturases illuminate the architectural and functional roles of these multidomain proteins in splicing and DNA invasion. The maturases show striking structural and functional homology to a central protein involved in spliceosomal premessenger RNA splicing, solidifying the idea that group II introns and the spliceosome descended from a common ancestor, an ancient retroelement.
II 类内含子成熟酶的首批高分辨率结构视图揭示了这些多结构域蛋白在剪接和 DNA 侵入过程中的结构和功能作用。这些成熟酶与参与剪接体前体信使 RNA 剪接的一种核心蛋白在结构和功能上表现出显著的同源性，强化了 II 类内含子和剪接体起源于共同祖先（一种古老的反转录元件）的观点。
