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非编码RNA与Ku和DNA依赖蛋白激酶催化亚基共同作用，增强乳腺癌细胞对DNA断裂的抗性

Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.

作者信息

Lees-Miller Susan P, Beattie Tara L, Tainer John A

机构信息

Department of Biochemistry and Molecular Biology, Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

出版信息

Nat Struct Mol Biol. 2016 Jun 7;23(6):509-10. doi: 10.1038/nsmb.3240.

DOI:10.1038/nsmb.3240
PMID:27273637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5549438/
Abstract

The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.

摘要

非编码RNA LINP1作为一种支架，连接Ku和DNA-PKcs，并通过非同源末端连接（NHEJ）实现高效的DNA双链断裂修复，从而增强三阴性乳腺癌细胞对放疗和化疗的抗性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e76/5549438/2a1dc6788993/nihms888281f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e76/5549438/2a1dc6788993/nihms888281f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e76/5549438/2a1dc6788993/nihms888281f1.jpg

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本文引用的文献

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Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer.长链非编码RNA LINP1调节三阴性乳腺癌中DNA双链断裂的修复。
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2
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.癌症基因组中的易位和缺失断点与潜在的非B型DNA形成序列相关。
Nucleic Acids Res. 2016 Jul 8;44(12):5673-88. doi: 10.1093/nar/gkw261. Epub 2016 Apr 15.
3
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.全面分析人类癌症中的长非编码 RNA 基因组特征。
Cancer Cell. 2015 Oct 12;28(4):529-540. doi: 10.1016/j.ccell.2015.09.006.
4
DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication.DNA依赖蛋白激酶催化亚基（DNA-PKcs）使核不均一核糖核蛋白A1（hnRNP-A1）磷酸化，以促进复制后RPA（复制蛋白A）向POT1（端粒保护蛋白1）的转换以及端粒封端。
Nucleic Acids Res. 2015 Jul 13;43(12):5971-83. doi: 10.1093/nar/gkv539. Epub 2015 May 20.
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Non-homologous end joining: emerging themes and unanswered questions.非同源末端连接：新兴主题和未解决的问题。
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