免疫疗法在头颈部鳞状细胞癌（HNSCC）中的新作用：抗肿瘤免疫与临床应用。
The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications.
机构信息
1 Department of Internal Medicine, Section of Medical Oncology, Attikon University Hospital, National Kapodistrian University of Athens, School of Medicine, Haidari, Athens, Greece ; 2 Department of Maxillofacial and Oral Surgery, Medical University of Vienna, 1090 Vienna, Austria ; 3 Department of Otorhinolaryngology, Facial Plastic and Reconstructive Surgery, Städtisches Klinikum Karlsruhe, 76133 Karlsruhe, Germany.
出版信息
Ann Transl Med. 2016 May;4(9):173. doi: 10.21037/atm.2016.03.34.
Abstract
Head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, with low survival rates for advanced stage tumors and minimal improvement in survival trends through the past decades. It is becoming increasingly clear that HNSCC oncogenesis and evolution is characterized by profound immune defects, as cancer cells evade immunosurveillance due to accumulation of genetic mutations and tumor heterogeneity. Improved understanding of the role of the immune system in cancer has led to the identification of novel therapeutic targets, which are being investigated for their potential to provide durable responses. In this review, we will summarize the role of the immune system in HNSCC, the rationale behind immunotherapy strategies and their clinical applications.
摘要
头颈部鳞状细胞癌（HNSCC）预后不良，晚期肿瘤的生存率低，过去几十年来生存率的改善甚微。越来越明显的是，HNSCC 的发生和发展具有严重的免疫缺陷，因为癌细胞由于遗传突变和肿瘤异质性的积累而逃避免疫监视。对免疫系统在癌症中的作用的认识的提高导致了新的治疗靶点的鉴定，这些靶点正在被研究以确定其提供持久反应的潜力。在这篇综述中，我们将总结免疫系统在 HNSCC 中的作用、免疫治疗策略的原理及其临床应用。
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