2015年马什哈德临床实验室送检患者的维生素D水平及其与患者血脂谱关系的研究

Study of the Vitamin D Levels in Patients Referred to Clinical Laboratories in Mashhad in 2015 and their Relationship with the Patients' Lipid Profiles.

作者信息

Shamsian Ali Akbar, Rezaee Seyyed Abdolrahim, Rajabiian Majid, Moghaddam Habibolah Taghizadeh, Saeidi Masumeh, Bahreini Abbas

机构信息

Department of Medical Parasitology and Mycology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Immunology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Electron Physician. 2016 Apr 25;8(4):2269-73. doi: 10.19082/2269. eCollection 2016 Apr.

DOI:10.19082/2269

PMID:27280003

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4886569/

Abstract

INTRODUCTION

Vitamin D is a steroid hormone that has a significant role in the metabolism of minerals, especially calcium and phosphorus; it also is a major determinant of the strength of bones. This hormone has a significant effect on three major health issues that people worldwide encounter, i.e., high blood pressure, cancer, and diabetes. Considering the limited and dispersed studies on the prevalence of vitamin D deficiency in Iran and the relationship of vitamin D with lipid profiles in different people, this study was conducted to determine the vitamin D levels in patients and its relationship with their lipid profiles.

METHODS

A retrospective cross-sectional study was conducted in 2015 on 1,110 patients who were referred to the two laboratories at Jihad Daneshgahi and to eight specialist laboratories in Mashhad through random sampling of patients for whom serum vitamin D and serum lipid tests were prescribed. The data that were obtained were entered into SPSS 13 software.

RESULTS

Sixty-eight percent of the patients in the study were deficient in vitamin D. The vitamin D levels in males were significantly lower than those in females (p < 0.05). The relationship between age and vitamin D deficiency was significant as well (p < 0.05). A positive and significant relationship was observed between age and vitamin D deficiency (p = 0.000, r = 0.187), i.e., vitamin D deficiency was more apparent in patients whose ages were in the range of 40-59. The relationship between the levels of vitamin D and serum lipids was significant and positive (p = 0.05), with the exception of LDL.

CONCLUSION

About two-thirds of the population that was studied had a vitamin D deficiency. There was a positive and significant relationship between serum vitamin D and serum lipids and serum calcium. The results of this study showed the necessity for more research and the implementation of preventive measures related to vitamin D deficiency. It is recommended that vitamin D enrichment programs be planned and implemented.

摘要

引言

维生素D是一种类固醇激素，在矿物质代谢尤其是钙和磷的代谢中起重要作用；它也是骨骼强度的主要决定因素。这种激素对全球人们面临的三大健康问题，即高血压、癌症和糖尿病有显著影响。鉴于伊朗关于维生素D缺乏症患病率以及维生素D与不同人群血脂谱关系的研究有限且分散，本研究旨在确定患者的维生素D水平及其与血脂谱的关系。

方法

2015年对1110名患者进行了一项回顾性横断面研究，这些患者是通过对开具血清维生素D和血脂检测医嘱的患者进行随机抽样，被转诊至圣战大学的两个实验室以及马什哈德的八个专科实验室的。所获数据录入SPSS 13软件。

结果

研究中68%的患者维生素D缺乏。男性的维生素D水平显著低于女性（p < 0.05）。年龄与维生素D缺乏之间的关系也很显著（p < 0.05）。年龄与维生素D缺乏之间存在显著正相关（p = 0.000，r = 0.187），即维生素D缺乏在年龄在40 - 59岁范围内的患者中更为明显。维生素D水平与血脂之间的关系显著且呈正相关（p = 0.05），低密度脂蛋白除外。