Nouri Saeidlou Sakineh, Vahabzadeh Davoud, Babaei Fariba, Vahabzadeh Zakaria
Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Maternal and Child Obesity Research Center (MCORC), Urmia University of Medical Sciences, Urmia, Iran.
J Health Popul Nutr. 2017 May 22;36(1):21. doi: 10.1186/s41043-017-0096-y.
Vitamin D has a multitude of functional properties and acts like a hormone in the body. Its effect on the lipid profile is one of the proposed mechanisms for its relationship with many disorders during its deficiency. But, this relationship is still conflicting and debatable, so this study was conducted to determine the association between serum level of vitamin D and lipid profiles, including serum concentrations of cholesterol, triglyceride (TG), HDL, and LDL in healthy subjects.
In this cross-sectional study, 541 volunteers with age of 5-60 years from normal and healthy subjects were selected via random sampling. Demographics and history of daily or weekly sunlight exposures were recorded. Measuring vitamin D was done in two consecutive seasons: winter and summer. Ten milliliters of peripheral venous blood sample was withdrawn after an overnight fasting. Serum levels of 25(OH) D (25, hydroxy vitamin D3) were measured using the enzyme-linked immunosorbent assay (ELISA), and the Confirmatory test was done by high-performance liquid chromatography (HPLC).
Mean age in the total mixed population was 30.83 ± 14.02 years. Subjects were 50.5% male and 49.5% female. Mean 25(OH) D in the total population for winter and summer were 45.8 ± 24.26 ng/ml and 55.24 ± 37.47 ng/ml respectively. In the total population, 38.08% were vitamin D deficient. Comparing serum lipid levels in the summer and winter showed a significant difference for cholesterol, LDL, and HDL, but no significant effect was found for TG. Analysis for the comparison of lipid profiles between the two genders in winter showed that there were significant differences in all lipid profiles except for LDL, while such analysis for summer revealed significant difference just for TG. In multivariate analysis, there was a significant mean difference only for LDL in subgroups with vitamin D insufficiency and deficiency. There was no correlation between Vitamin D and lipid profiles.
Vitamin D is different between the two seasons regardless of gender variations. Its status showed some significant relationship with some lipid profiles (cholesterol, LDL, and HDL) during the two seasons. There were different results among winter and summer based on the gender.
维生素D具有多种功能特性，在体内起着激素的作用。其对血脂谱的影响是其在缺乏时与许多疾病关系的一种推测机制。但是，这种关系仍然存在冲突且有争议，因此进行本研究以确定健康受试者血清维生素D水平与血脂谱之间的关联，包括血清胆固醇、甘油三酯（TG）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）浓度。
在这项横断面研究中，通过随机抽样从正常健康受试者中选取了541名年龄在5至60岁之间的志愿者。记录人口统计学信息以及每日或每周阳光暴露史。在冬季和夏季这两个连续季节测量维生素D。空腹过夜后抽取10毫升外周静脉血样本。使用酶联免疫吸附测定法（ELISA）测量血清25（OH）D（25-羟基维生素D3）水平，并通过高效液相色谱法（HPLC）进行确证试验。
总混合人群的平均年龄为30.83±14.02岁。受试者中男性占50.5%，女性占49.5%。冬季和夏季总人群的平均25（OH）D分别为45.8±24.26 ng/ml和55.24±37.47 ng/ml。在总人群中，38.08%的人维生素D缺乏。比较夏季和冬季的血清脂质水平，发现胆固醇、低密度脂蛋白和高密度脂蛋白有显著差异，但甘油三酯没有显著影响。冬季对两性血脂谱比较的分析表明，除低密度脂蛋白外，所有血脂谱均存在显著差异，而夏季的此类分析仅显示甘油三酯有显著差异。在多变量分析中，维生素D不足和缺乏亚组中仅低密度脂蛋白存在显著平均差异。维生素D与血脂谱之间无相关性。
无论性别差异如何，两个季节的维生素D水平都不同。其状态在两个季节与某些血脂谱（胆固醇、低密度脂蛋白和高密度脂蛋白）显示出一些显著关系。基于性别的冬季和夏季结果不同。
