伊朗2型糖尿病患者血清维生素D水平与血脂谱之间的关联。
Association between serum level of vitamin D and lipid profiles in type 2 diabetic patients in Iran.
作者信息
Saedisomeolia Ahmad, Taheri Ehsaneh, Djalali Mahmoud, Moghadam Ali Malekshahi, Qorbani Mostafa
机构信息
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Diabetes Metab Disord. 2014 Jan 7;13(1):7. doi: 10.1186/2251-6581-13-7.
BACKGROUND
It is suggested that vitamin D deficiency is associated with cardiovascular disease (CVD) via its effect on lipid profiles. The objective of this study was to determine the association between fasting serum levels of 25(OH) D and lipid profiles in patients with type 2 diabetes.
METHODS
This cross-sectional study was conducted on 108 type 2 diabetics. Patients were selected randomly among members of the Iranian Diabetes Association according to study criteria. Fasting concentration of 25(OH) D, calcium, phosphorus, parathyroid hormone (PTH) and lipid profiles (including triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol) were measured.
RESULTS
The mean serum levels of 25-hydroxyvitamin D (25(OH) D) and PTH were 53.41 ± 33.25 nmol/l and 40.24 ± 18.24 pmol/l, respectively, in type 2 diabetic patients. Prevalence of vitamin D deficiency was 58.34% and vitamin D sufficiency and insufficiency combined was 41.66%. Although in diabetic patients with vitamin D deficiency, serum levels of total cholesterol, TG, and LDL were higher and HDL was lower compared to patients with vitamin D sufficiency, this association was statistically significant only for serum level of TG (145.91 ± 79.00 vs. 122.95 ± 55.82 mg/dl).
CONCLUSIONS
The results of present study show that serum concentrations of 25(OH) D were inversely associated with TG. More interventional studies are needed to confirm the relationship between serum concentration of vitamin D and lipid profile in patients with type 2 diabetes.
背景
有研究表明，维生素D缺乏通过影响血脂水平与心血管疾病（CVD）相关。本研究的目的是确定2型糖尿病患者空腹血清25（OH）D水平与血脂水平之间的关联。
方法
本横断面研究共纳入108例2型糖尿病患者。根据研究标准，从伊朗糖尿病协会成员中随机选取患者。测量空腹状态下的25（OH）D、钙、磷、甲状旁腺激素（PTH）以及血脂水平（包括甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和总胆固醇）。
结果
2型糖尿病患者血清25-羟维生素D（25（OH）D）和PTH的平均水平分别为53.41±33.25 nmol/l和40.24±18.24 pmol/l。维生素D缺乏的患病率为58.34%，维生素D充足和不足的合并患病率为41.66%。虽然与维生素D充足的患者相比，维生素D缺乏的糖尿病患者血清总胆固醇、TG和LDL水平较高，HDL水平较低，但这种关联仅在血清TG水平上具有统计学意义（145.91±79.00 vs. 122.95±55.82 mg/dl）。
结论
本研究结果表明，血清25（OH）D浓度与TG呈负相关。需要更多的干预性研究来证实2型糖尿病患者血清维生素D浓度与血脂水平之间的关系。
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