Minea Bogdan, Nastasa Valentin, Kolecka Anna, Mares Magdalena, Marangoci Narcisa, Rosca Irina, Pinteala Mariana, Hancianu Monica, Mares Mihai
Pol J Microbiol. 2016;65(1):123-9. doi: 10.5604/17331331.1197327.
This is the first Romanian investigation of oral candidosis in patients suffering of HIV-infection or type 1 diabetes mellitus (T1DM). Candida albicans was the dominant species in both types of isolates: n = 14 (46.7%) in T1DM, n = 60 (69.8%) in HIV. The most frequent non-albicans Candida spp. were Candida kefyr (n = 6; 20%) in T1DM and Candida dubliniensis (n = 8; 9.3%) in HIV. Resistance to fluconazole was detected only in the HIV non-albicans Candida group (n = 8; 9.3%). All isolates were susceptible to VOR. The experimental drug MXP had MIC values equal or close to the ones of VOR. Echinocandin resistance was more frequent than azole resistance.
这是罗马尼亚首次针对感染人类免疫缺陷病毒（HIV）或1型糖尿病（T1DM）患者的口腔念珠菌病展开的调查。白色念珠菌在两种类型的分离株中均为优势菌种：在T1DM患者中为14株（46.7%），在HIV患者中为60株（69.8%）。最常见的非白色念珠菌在T1DM患者中为解脂念珠菌（6株；20%），在HIV患者中为都柏林念珠菌（8株；9.3%）。仅在HIV非白色念珠菌组中检测到对氟康唑的耐药性（8株；9.3%）。所有分离株对伏立康唑均敏感。实验药物MXP的最低抑菌浓度（MIC）值等于或接近伏立康唑。棘白菌素耐药性比唑类耐药性更为常见。
