Jung Hye Jin, Kim Young-Ho, Kim You Sun, Jeong Seong Yeon, Park Sung Won, Seo Ji Yeon, Jung Hyemi, Im Jong Pil, Kim Ji Won, Hong Sung Noh, Lee Kuk Lae
Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea.
Department of Health Promotion Center, International St. Mary's Hospital, Incheon, Korea.
Gut Liver. 2016 Jul 16;10(4):649-52. doi: 10.5009/gnl15439.
Intestinal tuberculosis (ITB) remains prevalent in Asia. An interferon-γ assay (QuantiFERON-TB gold test [QFT]) is considered to be an effective supplementary tool for diagnosing ITB. We retrospectively analyzed the clinical features of ITB patients based on the initial results of QFT. A total of 109 patients with ITB were enrolled, and 82 patients (75.2%) showed positive QFT results. In the QFT-positive group, the mean age (44.1±12.0 years) was significantly higher than that in the QFT-negative group (37.0±14.8, p=0.0096). Abdominal pain (p=0.006) and diarrhea (p=0.030) were more frequent in the QFT-negative group. Further, C-reactive protein (CRP) levels were significantly higher in the QFTnegative group (6.4±9.9 mg/dL) than in the QFT-positive group (1.3±2.3, p<0.001). Multivariate analysis confirmed that younger age (p=0.016), diarrhea (p=0.042), and high levels of CRP (p=0.029) were independent predictors of QFTnegative results in patients with ITB. These results suggest that prior exposure to TB, reflected by QFT positivity, may cause mild inflammation in patients with ITB.
肠结核（ITB）在亚洲仍然普遍存在。干扰素-γ检测（结核感染T细胞检测[QFT]）被认为是诊断ITB的一种有效辅助工具。我们根据QFT的初始结果对ITB患者的临床特征进行了回顾性分析。共纳入109例ITB患者，其中82例（75.2%）QFT结果呈阳性。在QFT阳性组中，平均年龄（44.1±12.0岁）显著高于QFT阴性组（37.0±14.8岁，p=0.0096）。QFT阴性组腹痛（p=0.006）和腹泻（p=0.030）更为常见。此外，QFT阴性组的C反应蛋白（CRP）水平（6.4±9.9mg/dL）显著高于QFT阳性组（1.3±2.3，p<0.001）。多变量分析证实，年龄较小（p=0.016）、腹泻（p=0.042）和CRP水平较高（p=0.029）是ITB患者QFT阴性结果的独立预测因素。这些结果表明，QFT阳性反映的既往结核暴露可能会导致ITB患者出现轻度炎症。
