Rudenko L G, Shvartsman Ia S, Ispolatova A V, Grigor'eva E P, Drinevskiĭ V P
Vopr Virusol. 1989 Jan-Feb;34(1):29-34.
The study of safety and immunizing properties of a live influenza vaccine from influenza viruses type A (H1N1) and A (H3N2) used separately and in combination was carried out in 2461 children ranging in age from 3 to 15 years. The possibility of combining two influenza type A viruses with similar biological activity was demonstrated. The vaccine exerted no harmful effect in children and actively stimulated the production of antihemagglutinating, antineuraminidase, and secretory antibodies and enhanced the formation of cell-mediated immunity.
对2461名3至15岁儿童进行了一项研究，该研究分别单独使用以及联合使用甲型（H1N1）和甲型（H3N2）流感病毒活疫苗，观察其安全性和免疫特性。研究证明了将两种具有相似生物学活性的甲型流感病毒联合使用的可能性。该疫苗对儿童无有害影响，能有效刺激抗血凝素、抗神经氨酸酶和分泌性抗体的产生，并增强细胞介导免疫的形成。
