Kim Samuel K, Wu Cheng-Chia, Horowitz David P
Department of Radiation Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA.
J Gastrointest Oncol. 2016 Jun;7(3):479-86. doi: 10.21037/jgo.2015.10.01.
With recent advances in imaging modalities and radiation therapy, stereotactic body radiotherapy (SBRT) has allowed for the delivery of high doses of radiation with accuracy and precision. As such, SBRT has generated favorable results in the treatment of several cancers. Although the role of radiation has been controversial for the treatment of pancreatic ductal adenocarcinoma (PDAC) due to rather lackluster results in clinical trials, SBRT may offer improved outcomes, enhance the quality of life, and aid in palliative care settings for PDAC patients. This review delineates the role of SBRT in the treatment of PDAC, presents the defining principles of radiation biology and the radiation oncology work flow, and discusses the prospects of new treatment regimens involving tumor immunology and radiation therapy.
随着成像技术和放射治疗的最新进展，立体定向体部放射治疗（SBRT）已能够精确地给予高剂量辐射。因此，SBRT在多种癌症的治疗中取得了良好效果。尽管由于临床试验结果相当平淡，放射治疗在胰腺导管腺癌（PDAC）治疗中的作用一直存在争议，但SBRT可能会改善PDAC患者的治疗效果、提高生活质量并有助于姑息治疗。本文综述阐述了SBRT在PDAC治疗中的作用，介绍了放射生物学的定义原则和放射肿瘤学工作流程，并讨论了涉及肿瘤免疫学和放射治疗的新治疗方案的前景。
