Castelli Tommaso, Russo Giorgio Ivan, Reale Giulio, Privitera Salvatore, Chisari Mario, Fragalà Eugenia, Favilla Vincenzo, Cimino Sebastiano, Morgia Giuseppe
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Int Braz J Urol. 2016 May-Jun;42(3):422-30. doi: 10.1590/S1677-5538.IBJU.2015.0095.
Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels. The aim of this review is to evaluate the role of the most important polyphenols on these two urological diseases. As antioxidants these compounds seems to have a direct action on the cell cycle and hormone function, important for both prostate cancer and BPH. Despite a large number of articles about the relationship of the polyphenols with prostate cancer, very little evidence exists for BPH. Additional clinical trials or meta-analysis are necessary on this topic.
良性前列腺增生和前列腺癌是两种常见的老年泌尿系统疾病。科学界一直在寻找一种联系，以解释这两种疾病之间的关联以及慢性炎症在良性前列腺增生和前列腺癌发病机制中的作用。正如这两种疾病与氧化应激和代谢综合征关系的报告所示，因此使用具有抗氧化作用的化合物可能会影响症状及其发作。多酚似乎不仅对氧化应激有作用，而且在不同层面上也有作用。本综述的目的是评估最重要的多酚对这两种泌尿系统疾病的作用。作为抗氧化剂，这些化合物似乎对细胞周期和激素功能有直接作用，这对前列腺癌和良性前列腺增生都很重要。尽管有大量关于多酚与前列腺癌关系的文章，但关于良性前列腺增生的证据却很少。关于这个主题，有必要进行更多的临床试验或荟萃分析。
