Udensi Udensi K, Tchounwou Paul B
NIH/NIMHD RCMI Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, Jackson, MS, 39217, USA.
J Exp Clin Cancer Res. 2016 Sep 8;35(1):139. doi: 10.1186/s13046-016-0418-8.
Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on its severity. Oxidative stress (OS) is known to influence the activities of inflammatory mediators and other cellular processes involved in the initiation, promotion and progression of human neoplasms including prostate cancer. Scientific evidence also suggests that micronutrient supplementation may restore the antioxidant status and hence improve the clinical outcomes for patients with BPH and PCa. This review highlights the recent studies on prostate hyperplasia and carcinogenesis, and examines the role of OS on the molecular pathology of prostate cancer progression and treatment.
前列腺增生（PH）是一种常见的泌尿系统疾病，主要影响老年男性。根据严重程度，PH可分为良性前列腺增生（BPH）或前列腺癌（PCa）。已知氧化应激（OS）会影响炎症介质的活性以及参与包括前列腺癌在内的人类肿瘤发生、发展和进展的其他细胞过程。科学证据还表明，补充微量营养素可能恢复抗氧化状态，从而改善BPH和PCa患者的临床结局。本综述重点介绍了前列腺增生和致癌作用的最新研究，并探讨了OS在前列腺癌进展和治疗分子病理学中的作用。
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