Bhandari Rohit, Gupta Prachi, Dziubla Thomas, Hilt J Zach
Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY 40506.
Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY 40506.
Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:59-64. doi: 10.1016/j.msec.2016.04.093. Epub 2016 Apr 28.
Magnetic iron oxide nanoparticles have been well known for their applications in magnetic resonance imaging (MRI), hyperthermia, targeted drug delivery, etc. The surface modification of these magnetic nanoparticles has been explored extensively to achieve functionalized materials with potential application in biomedical, environmental and catalysis field. Herein, we report a novel and versatile single step methodology for developing curcumin functionalized magnetic Fe3O4 nanoparticles without any additional linkers, using a simple coprecipitation technique. The magnetic nanoparticles (MNPs) were characterized using transmission electron microscopy, X-ray diffraction, fourier transform infrared spectroscopy and thermogravimetric analysis. The developed MNPs were employed in a cellular application for protection against an inflammatory agent, a polychlorinated biphenyl (PCB) molecule.
磁性氧化铁纳米颗粒因其在磁共振成像(MRI)、热疗、靶向药物递送等方面的应用而广为人知。人们对这些磁性纳米颗粒的表面改性进行了广泛探索,以获得在生物医学、环境和催化领域具有潜在应用价值的功能化材料。在此,我们报告了一种新颖且通用的单步方法,通过简单的共沉淀技术,无需任何额外的连接剂即可制备姜黄素功能化的磁性Fe3O4纳米颗粒。使用透射电子显微镜、X射线衍射、傅里叶变换红外光谱和热重分析对磁性纳米颗粒(MNPs)进行了表征。所制备的MNPs被用于细胞应用中,以保护细胞免受炎症介质多氯联苯(PCB)分子的侵害。