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奥托·奥夫兰克奖:门诊与住院全髋关节置换术的多中心随机研究。

Otto Aufranc Award: A Multicenter, Randomized Study of Outpatient versus Inpatient Total Hip Arthroplasty.

作者信息

Goyal Nitin, Chen Antonia F, Padgett Sarah E, Tan Timothy L, Kheir Michael M, Hopper Robert H, Hamilton William G, Hozack William J

机构信息

Anderson Orthopaedic Research Institute & Inova Center for Joint Replacement at Mount Vernon Hospital, 2501 Parkers Lane, Suite 200, Alexandria, VA, 22306, USA.

The Rothman Institute & Thomas Jefferson University Hospital, Philadelphia, PA, USA.

出版信息

Clin Orthop Relat Res. 2017 Feb;475(2):364-372. doi: 10.1007/s11999-016-4915-z.

Abstract

BACKGROUND

Length of stay after total hip arthroplasty (THA) has decreased over the last two decades. However, published studies that have examined same-day and early discharge protocols after THA have been done in highly selected patient groups operated on by senior surgeons in a nonrandomized fashion without control subjects.

QUESTIONS/PURPOSES: The purpose of this study was to evaluate and compare patients undergoing THA who are discharged on the same day as the surgery ("outpatient," less than 12-hour stay) with those who are discharged after an overnight hospital stay ("inpatient") with regard to the following outcomes: (1) postoperative pain; (2) perioperative complications and healthcare provider visits (readmission, emergency department or physician office); and (3) relative work effort for the surgeon's office staff.

METHODS

A prospective, randomized study was conducted at two high-volume adult reconstruction centers between July 2014 and September 2015. Patients who were younger than 75 years of age at surgery, who could ambulate without a walker, who were not on chronic opioids, and whose body mass index was less than 40 kg/m were invited to participate. All patients had a primary THA performed by the direct anterior approach with spinal anesthesia at a hospital facility. Study data were evaluated using an intention-to-treat analysis. A total of 220 patients participated, of whom 112 were randomized to the outpatient group and 108 were randomized to the inpatient group. Of the 112 patients randomized to outpatient surgery, 85 (76%) were discharged as planned. Of the remaining 27 patients, 26 were discharged after one night in the hospital and one was discharged after two nights. Of the 108 patients randomized to inpatient surgery with an overnight hospital stay, 81 (75%) were discharged as planned. Of the remaining 27 patients, 18 met the discharge criteria on the day of their surgery and elected to leave the same day, whereas nine patients stayed two or more nights.

RESULTS

On the day of surgery, there was no difference in visual analog scale (VAS) pain among patients who were randomized to discharge on the same day and those who were randomized to remain in the hospital overnight (outpatient 2.8 ± 2.5, inpatient 3.3 ± 2.3, mean difference -0.5, 95% confidence interval [CI], -1.1 to 0.1, p = 0.12). On the first day after surgery, outpatients had higher VAS pain (at home) than inpatients (3.7 ± 2.3 versus 2.8 ± 2.1, mean difference 0.9, 95% CI, 0.3-1.5, p = 0.005). With the numbers available, there was no difference in the number of reoperations, hospital readmissions without reoperation, emergency department visits without hospital readmission, or acute office visits. At 4-week followup, there was no difference in the number of phone calls and emails with the surgeon's office (outpatient: 2.4 ± 1.9, inpatient: 2.4 ± 2.2, mean difference 0, 95% CI, -0.5 to 0.6, p = 0.94).

CONCLUSIONS

Outpatient THA can be implemented in a defined patient population without requiring additional work for the surgeon's office. Because 24% (27 of 112) of patients planning to have outpatient surgery were not able to be discharged the same day, facilities to accommodate an overnight stay should be available.

LEVEL OF EVIDENCE

Level I, therapeutic study.

摘要

背景

在过去二十年中,全髋关节置换术(THA)后的住院时间有所缩短。然而,已发表的关于THA术后当日出院和早期出院方案的研究,是在经过高度筛选的患者群体中进行的,由资深外科医生以非随机方式实施手术,且没有对照组。

问题/目的:本研究的目的是评估和比较接受THA手术且在手术当日出院(“门诊患者”,住院时间少于12小时)的患者与住院一晚后出院(“住院患者”)的患者在以下方面的结果:(1)术后疼痛;(2)围手术期并发症和医疗服务提供者就诊情况(再次入院、急诊或医生办公室就诊);(3)外科医生办公室工作人员的相关工作负担。

方法

2014年7月至2015年9月期间,在两个大型成人重建中心进行了一项前瞻性随机研究。邀请手术时年龄小于75岁、无需助行器即可行走、未使用慢性阿片类药物且体重指数小于40kg/m²的患者参与。所有患者均在医院设施中采用直接前路入路和脊髓麻醉进行初次THA手术。研究数据采用意向性分析进行评估。共有220例患者参与,其中112例随机分配至门诊组,108例随机分配至住院组。在随机分配至门诊手术的112例患者中,85例(76%)按计划出院。其余27例患者中,26例在住院一晚后出院,1例在住院两晚后出院。在随机分配至住院一晚的住院手术的108例患者中,81例(75%)按计划出院。其余27例患者中,18例在手术当天符合出院标准并选择当日出院,而9例患者住院两晚或更长时间。

结果

手术当天,随机分配至当日出院的患者与随机分配至住院一晚的患者在视觉模拟量表(VAS)疼痛评分上无差异(门诊患者2.8±2.5,住院患者3.3±2.3,平均差异-0.5,95%置信区间[CI],-1.1至0.1,p=0.12)。术后第一天,门诊患者(在家时)的VAS疼痛评分高于住院患者(3.7±2.3对2.8±2.1,平均差异0.9,95%CI,0.3 - 1.5,p=0.005)。就现有数据而言,再次手术、未再次手术的医院再入院、未医院再入院的急诊就诊或急性门诊就诊的次数无差异。在4周随访时,与外科医生办公室的电话和电子邮件沟通次数无差异(门诊患者:2.4±1.9,住院患者:2.4±2.2,平均差异0,95%CI,-0.5至0.6,p=0.94)。

结论

门诊THA可在特定患者群体中实施,无需外科医生办公室增加额外工作。由于计划进行门诊手术的患者中有24%(112例中的27例)无法在当日出院,应具备提供过夜住宿的设施。

证据水平

I级,治疗性研究。

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